FOG14614
EOG8F1VJJ

sce:YKU70

Genes: 32

SGD Description
Subunit of the telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein to nucleus via interaction with the TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair


PomBase Description
Ku domain protein Pku70


AspGD Description
Ku70 ortholog involved in non-homologous end-joining


References

Feldmann H, et al. (1993 Jun 15). A putative homologue of the human autoantigen Ku from Saccharomyces cerevisiae.

Yoshida M, et al. (1994 Mar). Cloning and sequencing of the NES24 gene of Saccharomyces cerevisiae.

Mages GJ, et al. (1996 Apr 5). Involvement of the Saccharomyces cerevisiae HDF1 gene in DNA double-strand break repair and recombination.

Tsukamoto Y, et al. (1996 Jun 1). Hdf1, a yeast Ku-protein homologue, is involved in illegitimate recombination, but not in homologous recombination.

Evans SK, et al. (1998 Dec). Telomerase, Ku, and telomeric silencing in Saccharomyces cerevisiae.

Polotnianka RM, et al. (1998 Jul 2). The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities.

Laroche T, et al. (1998 May 21). Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres.

Nugent CI, et al. (1998 May 21). Telomere maintenance is dependent on activities required for end repair of double-strand breaks.

de la Torre-Ruiz M, et al. (2000 Feb 11). The Saccharomyces cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non-homologous end joining.

Grandin N, et al. (2000 Nov). Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment.

Tsai YL, et al. (2002 Aug). Involvement of replicative polymerases, Tel1p, Mec1p, Cdc13p, and the Ku complex in telomere-telomere recombination.

Bertuch AA, et al. (2003 Nov). The Ku heterodimer performs separable activities at double-strand breaks and chromosome termini.

Stellwagen AE, et al. (2003 Oct 1). Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends.

Zhao X, et al. (2005 Mar 29). A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.

Liti G, et al. (2006 Oct). Sequence diversity, reproductive isolation and species concepts in Saccharomyces.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%