FOG14574
EOG8F4QTR

sce:CDC55

Genes: 33

SGD Description
Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); localization to cytoplasm requires Zds1p and Zds2p and promotes mitotic entry; localization to nucleus prevents mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains nucleolar sequestration of Cdc14p during early meiosis; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; homolog of mammalian B55


PomBase Description
protein phosphatase regulatory subunit Pab1


AspGD Description
Ortholog(s) have protein serine/threonine phosphatase activity


References

JANSEN GJ, et al. (1964). UV-INDUCED MITOTIC RECOMBINATION IN THE PABA-1 REGION AF ASPERGILLUS NIDULANS.

Sukhanova ES, et al. (1977). [Genetic control of recombination processes in Aspergillus nidulans. I. Effect of uvs-mutations on the frequency of spontaneous and ultraviolet ray-induced intergenic recombination].

Zucchi TM, et al. (1989). RNA-mediated genetic transformation in Aspergillus nidulans.

Healy AM, et al. (1991 Nov). CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase.

Jimenez J, et al. (1994 Oct 17). Ethanol-hypersensitive and ethanol-dependent cdc- mutants in Schizosaccharomyces pombe.

Kinoshita K, et al. (1996 Jan). The regulatory subunits of fission yeast protein phosphatase 2A (PP2A) affect cell morphogenesis, cell wall synthesis and cytokinesis.

Le Goff X, et al. (2001 Nov 9). The protein phosphatase 2A B'-regulatory subunit par1p is implicated in regulation of the S. pombe septation initiation network.

Baptista F, et al. (2002). uvsZ1 mutation shows epistatic relations with uvsD153 and uvsJ1 mutations without any involvement with checkpoint control in Aspergillus nidulans.

Maoz T, et al. (2005 Dec 16). YND1 interacts with CDC55 and is a novel mediator of E4orf4-induced toxicity.

Hanyu Y, et al. (2009 May). Schizosaccharomyces pombe cell division cycle under limited glucose requires Ssp1 kinase, the putative CaMKK, and Sds23, a PP2A-related phosphatase inhibitor.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Han TX, et al. (2010). Global fitness profiling of fission yeast deletion strains by barcode sequencing.

Lahoz A, et al. (2010 Dec). Antagonistic roles of PP2A-Pab1 and Etd1 in the control of cytokinesis in fission yeast.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Goyal A, et al. (2012 Apr). Characterization of ypa1 and ypa2, the Schizosaccharomyces pombe orthologs of the peptidyl proyl isomerases that activate PP2A, reveals a role for Ypa2p in the regulation of cytokinesis.

Pan X, et al. (2012 Nov 23). Identification of novel genes involved in DNA damage response by screening a genome-wide Schizosaccharomyces pombe deletion library.

Tang Z, et al. (2012 Oct 1). Interacting factors and cellular localization of SR protein-specific kinase Dsk1.

Zhou X, et al. (2013). A genome-wide screening of potential target genes to enhance the antifungal activity of micafungin in Schizosaccharomyces pombe.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Zhong GW, et al. (2014 Dec). Protein phosphatase 2A (PP2A) regulatory subunits ParA and PabA orchestrate septation and conidiation and are essential for PP2A activity in Aspergillus nidulans.

Alcaide-Gavilán M, et al. (2014 Feb). Feedback regulation of SIN by Etd1 and Rho1 in fission yeast.

Bernal M, et al. (2014 Jun). Proteome-wide search for PP2A substrates in fission yeast.

Grallert A, et al. (2015 Jan 1). A PP1-PP2A phosphatase relay controls mitotic progression.

Chica N, et al. (2016 Feb 8). Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway.

Nie M, et al. (2016 Jul). Functional Crosstalk between the PP2A and SUMO Pathways Revealed by Analysis of STUbL Suppressor, razor 1-1.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Lucena R, et al. (2017 Mar 4). Wee1 and Cdc25 are controlled by conserved PP2A-dependent mechanisms in fission yeast.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%