FOG14543
EOG8F7M14

sce:GCN5

Genes: 34

SGD Description
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes; modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; relocalizes to the cytosol in response to hypoxia; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation


PomBase Description
SAGA complex histone acetyltransferase catalytic subunit Gcn5


AspGD Description
Ortholog(s) have H3 histone acetyltransferase activity, lysine-acetylated histone binding activity|Ortholog(s) have H3 histone acetyltransferase activity, role in histone acetylation, nucleosome positioning and SAGA complex localization


References

Georgakopoulos T, et al. (1992 Nov). Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription.

Marcus GA, et al. (1994 Oct 17). Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.

Horiuchi J, et al. (1997 Jun). ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.

Grant PA, et al. (1998 Dec). The ATM-related cofactor Tra1 is a component of the purified SAGA complex.

Trievel RC, et al. (1999 Aug 3). Crystal structure and mechanism of histone acetylation of the yeast GCN5 transcriptional coactivator.

Grant PA, et al. (1999 Feb 26). Expanded lysine acetylation specificity of Gcn5 in native complexes.

Eberharter A, et al. (1999 Oct). The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae.

Dyda F, et al. (2000). GCN5-related N-acetyltransferases: a structural overview.

Suka N, et al. (2001 Aug). Highly specific antibodies determine histone acetylation site usage in yeast heterochromatin and euchromatin.

Pray-Grant MG, et al. (2002 Dec). The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.

Sterner DE, et al. (2002 Sep 3). SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription.

Wu PY, et al. (2004 Jul 23). Molecular architecture of the S. cerevisiae SAGA complex.

Pray-Grant MG, et al. (2005 Jan 27). Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.

Babiarz JE, et al. (2006 Mar 15). Telomeric heterochromatin boundaries require NuA4-dependent acetylation of histone variant H2A.Z in Saccharomyces cerevisiae.

Millar CB, et al. (2006 Mar 15). Acetylation of H2AZ Lys 14 is associated with genome-wide gene activity in yeast.

Morris SA, et al. (2007 Mar 9). Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%