FOG14415
EOG8FJ6S5

sce:DPH2

Genes: 33

SGD Description
Protein required for synthesis of diphthamide; required along with Dph1p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p


PomBase Description
diphthamide biosynthesis protein (predicted)


AspGD Description
Ortholog(s) have role in peptidyl-diphthamide biosynthetic process from peptidyl-histidine and cytosol localization


References

Chéret G, et al. (1993 Jun). DNA sequence analysis of the YCN2 region of chromosome XI in Saccharomyces cerevisiae.

Mattheakis LC, et al. (1993 Sep 30). Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene.

Mendoza I, et al. (1994 Mar 25). The protein phosphatase calcineurin is essential for NaCl tolerance of Saccharomyces cerevisiae.

Fichtner L, et al. (2003 Sep). Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification.

Liu S, et al. (2004 Nov). Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 5 genes with posterior transmembrane prediction > 50%