FOG14375
EOG8FN31W

sce:CBF1

Genes: 33

SGD Description
Basic helix-loop-helix (bHLH) protein; forms homodimer to bind E-box consensus sequence CACGTG present at MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins, required for chromosome segregation; protein abundance increases in response to DNA replication stress


PomBase Description
transcription factor (predicted)


AspGD Description
Ortholog(s) have transcription factor activity, sequence-specific DNA binding, transcription regulatory region DNA binding activity and nucleus localization


References

Mellor J, et al. (1990 Dec). CPF1, a yeast protein which functions in centromeres and promoters.

Baker RE, et al. (1990 Jun). Isolation of the gene encoding the Saccharomyces cerevisiae centromere-binding protein CP1.

Cai M, et al. (1990 May 4). Yeast centromere binding protein CBF1, of the helix-loop-helix protein family, is required for chromosome stability and methionine prototrophy.

Thomas D, et al. (1992 Apr). MET4, a leucine zipper protein, and centromere-binding factor 1 are both required for transcriptional activation of sulfur metabolism in Saccharomyces cerevisiae.

Mulder W, et al. (1994 Sep). Centromere promoter factors (CPF1) of the yeasts Saccharomyces cerevisiae and Kluyveromyces lactis are functionally exchangeable, despite low overall homology.

Bergh KT, et al. (1996 Jul). Identification of a major cis-acting DNA element controlling the bidirectionally transcribed penicillin biosynthesis genes acvA (pcbAB) and ipnA (pcbC) of Aspergillus nidulans.

Litzka O, et al. (1996 Jun 15). The Aspergillus nidulans penicillin-biosynthesis gene aat (penDE) is controlled by a CCAAT-containing DNA element.

Kuras L, et al. (1996 May 15). A heteromeric complex containing the centromere binding factor 1 and two basic leucine zipper factors, Met4 and Met28, mediates the transcription activation of yeast sulfur metabolism.

Kuras L, et al. (1997 May 1). Assembly of a bZIP-bHLH transcription activation complex: formation of the yeast Cbf1-Met4-Met28 complex is regulated through Met28 stimulation of Cbf1 DNA binding.

Brakhage AA, et al. (1998 Sep). Molecular regulation of beta-lactam biosynthesis in filamentous fungi.

Eck R, et al. (2001 Aug). The centromere-binding factor Cbf1p from Candida albicans complements the methionine auxotrophic phenotype of Saccharomyces cerevisiae.

Caruso ML, et al. (2002 Oct 25). Novel basic-region helix-loop-helix transcription factor (AnBH1) of Aspergillus nidulans counteracts the CCAAT-binding complex AnCF in the promoter of a penicillin biosynthesis gene.

Biswas K, et al. (2003 Dec 24). Functional characterization of CaCBF1, the Candida albicans homolog of centromere binding factor 1.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Brakhage AA, et al. (2004). Regulation of penicillin biosynthesis in filamentous fungi.

Herrmann M, et al. (2006 Apr). Protein kinase C (PkcA) of Aspergillus nidulans is involved in penicillin production.

Hogues H, et al. (2008 Mar 14). Transcription factor substitution during the evolution of fungal ribosome regulation.

Spröte P, et al. (2008 Oct). Identification of the novel penicillin biosynthesis gene aatB of Aspergillus nidulans and its putative evolutionary relationship to this fungal secondary metabolism gene cluster.

Brakhage AA, et al. (2009 Oct-Nov). Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors.

Nobile CJ, et al. (2012 Jan 20). A recently evolved transcriptional network controls biofilm development in Candida albicans.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%