FOG14267
EOG8FXPQS

sce:BST1

Genes: 36

SGD Description
GPI inositol deacylase of the endoplasmic reticulum (ER); negatively regulates COPII vesicle formation; prevents production of vesicles with defective subunits; required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules; functional ortholog of human PGAP1, mutation of which is associated with intellectual disability and encephalopathy


PomBase Description
GPI inositol deacylase Bst1 (predicted)


AspGD Description
Ortholog(s) have Golgi apparatus, endoplasmic reticulum localization


References

Elrod-Erickson MJ, et al. (1996 Jul). Genes that control the fidelity of endoplasmic reticulum to Golgi transport identified as suppressors of vesicle budding mutations.

Vashist S, et al. (2001 Oct 29). Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding.

Tanaka S, et al. (2004 Apr 2). Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p.

Fujita M, et al. (2006 Feb). Inositol deacylation by Bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 34 genes with posterior transmembrane prediction > 50%