FOG14235
EOG8G1K0G

sce:NMT1

Genes: 32

SGD Description
N-myristoyl transferase; catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction


PomBase Description
N-myristoyltransferase Myr1 (predicted)


AspGD Description
Ortholog(s) have glycylpeptide N-tetradecanoyltransferase activity, role in establishment of cell polarity and cytosol localization


References

Towler DA, et al. (1987 May). Purification and characterization of yeast myristoyl CoA:protein N-myristoyltransferase.

Duronio RJ, et al. (1989 Feb 10). Disruption of the yeast N-myristoyl transferase gene causes recessive lethality.

Duronio RJ, et al. (1991 Jun). Myristic acid auxotrophy caused by mutation of S. cerevisiae myristoyl-CoA:protein N-myristoyltransferase.

Wiegand RC, et al. (1992 Apr 25). The Candida albicans myristoyl-CoA:protein N-myristoyltransferase gene. Isolation and expression in Saccharomyces cerevisiae and Escherichia coli.

Rudnick DA, et al. (1993 Feb 1). Use of photoactivatable peptide substrates of Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p) to characterize a myristoyl-CoA-Nmt1p-peptide ternary complex and to provide evidence for an ordered reaction mechanism.

Johnson DR, et al. (1993 Jan 5). Genetic and biochemical studies of a mutant Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase, nmt72pLeu99-->Pro, that produces temperature-sensitive myristic acid auxotrophy.

Lodge JK, et al. (1994 Jan 28). Comparison of myristoyl-CoA:protein N-myristoyltransferases from three pathogenic fungi: Cryptococcus neoformans, Histoplasma capsulatum, and Candida albicans.

Zhang L, et al. (1996 Dec 20). Biochemical studies of Saccharomyces cerevisiae myristoyl-coenzyme A:protein N-myristoyltransferase mutants.

McWherter CA, et al. (1997 May 2). Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition.

Bhatnagar RS, et al. (1998 Dec). Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs.

Weston SA, et al. (1998 Mar). Crystal structure of the anti-fungal target N-myristoyl transferase.

Momany M, et al. (1999 Feb). Aspergillus nidulans swo mutants show defects in polarity establishment, polarity maintenance and hyphal morphogenesis.

Farazi TA, et al. (2001 Aug 7). Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis.

Farazi TA, et al. (2001 May 29). Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.

Shaw BD, et al. (2002 Apr). Aspergillus nidulans swoF encodes an N-myristoyl transferase.

Momany M, et al. (2002 Dec). Polarity in filamentous fungi: establishment, maintenance and new axes.

Sogabe S, et al. (2002 Oct). Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors.

Momany M, et al. (2005 May). Growth control and polarization.

Lee SC, et al. (2007 Feb). A novel interaction between N-myristoylation and the 26S proteasome during cell morphogenesis.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%