FOG14165
EOG8G79FV

sce:SEN2

Genes: 33

SGD Description
Subunit of the tRNA splicing endonuclease; tRNA splicing endonuclease is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease


PomBase Description
tRNA-splicing endonuclease subunit catalytic subunit Sen2 (predicted)


AspGD Description
Ortholog(s) have cytoplasm localization


References

Ho CK, et al. (1990 Apr). Accumulation of pre-tRNA splicing '2/3' intermediates in a Saccharomyces cerevisiae mutant.

Rauhut R, et al. (1990 Oct 25). Yeast tRNA-splicing endonuclease is a heterotrimeric enzyme.

Trotta CR, et al. (1997 Jun 13). The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases.

Yoshihisa T, et al. (2003 Aug). Possibility of cytoplasmic pre-tRNA splicing: the yeast tRNA splicing endonuclease mainly localizes on the mitochondria.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%