FOG14006
EOG8GMSC7

sce:YBP1;YBP2

Genes: 27

SGD Description
Protein involved in cellular response to oxidative stress; required for oxidation of specific cysteine residues of transcription factor Yap1p, resulting in nuclear localization of Yap1p in response to stress; YBP1 has a paralog, YBP2, that arose from the whole genome duplication|Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication


References

Feuermann M, et al. (1997 Jul). The characterization of two new clusters of duplicated genes suggests a 'Lego' organization of the yeast Saccharomyces cerevisiae chromosomes.

Jelinsky SA, et al. (1999 Feb 16). Global response of Saccharomyces cerevisiae to an alkylating agent.

Ito T, et al. (2001 Apr 10). A comprehensive two-hybrid analysis to explore the yeast protein interactome.

de Jesus Ferreira MC, et al. (2001 Aug). Transposon mutagenesis reveals novel loci affecting tolerance to salt stress and growth at low temperature.

Veal EA, et al. (2003 Aug 15). Ybp1 is required for the hydrogen peroxide-induced oxidation of the Yap1 transcription factor.

Gulshan K, et al. (2004 Apr). YBP1 and its homologue YBP2/YBH1 influence oxidative-stress tolerance by nonidentical mechanisms in Saccharomyces cerevisiae.

Patterson MJ, et al. (2013 Dec 20). Ybp1 and Gpx3 signaling in Candida albicans govern hydrogen peroxide-induced oxidation of the Cap1 transcription factor and macrophage escape.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 15 genes with posterior transmembrane prediction > 50%