FOG13997
EOG83FFBM
EOG8GMSF3

sce:TRA1

Genes: 39

SGD Description
Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation


PomBase Description
NuA4 complex phosphatidylinositol pseudokinase complex subunit Tra2|SAGA complex phosphatidylinositol pseudokinase Tra1


AspGD Description
Ortholog(s) have histone acetyltransferase activity


References

Grant PA, et al. (1998 Dec). The ATM-related cofactor Tra1 is a component of the purified SAGA complex.

Saleh A, et al. (1998 Oct 9). Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes.

Grant PA, et al. (1999 Feb 26). Expanded lysine acetylation specificity of Gcn5 in native complexes.

Allard S, et al. (1999 Sep 15). NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p.

Brown CE, et al. (2001 Jun 22). Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit.

Pray-Grant MG, et al. (2002 Dec). The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.

Sterner DE, et al. (2002 Sep 3). SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription.

Wu PY, et al. (2004 Jul 23). Molecular architecture of the S. cerevisiae SAGA complex.

Pray-Grant MG, et al. (2005 Jan 27). Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.

Hayashi T, et al. (2007 Dec). Rapamycin sensitivity of the Schizosaccharomyces pombe tor2 mutant and organization of two highly phosphorylated TOR complexes by specific and common subunits.

Kanoh J, et al. (2007 Dec). Tel2: a common partner of PIK-related kinases and a link between DNA checkpoint and nutritional response?

Shevchenko A, et al. (2008). Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Helmlinger D, et al. (2011 Jun 3). Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

McDonald KR, et al. (2016 Sep). Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 29 genes with posterior transmembrane prediction > 50%