FOG13954
EOG8GQNPF

sce:DBR1

Genes: 33

SGD Description
RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies


PomBase Description
RNA lariat debranching enzyme Dbr1


AspGD Description
Ortholog(s) have RNA lariat debranching enzyme activity, role in RNA phosphodiester bond hydrolysis, endonucleolytic, mRNA cis splicing, via spliceosome and nucleus localization


References

Chapman KB, et al. (1991 May 3). Isolation and characterization of the gene encoding yeast debranching enzyme.

Schülke N, et al. (1992 Sep 1). Primary structure, import, and assembly of the yeast homolog of succinate dehydrogenase flavoprotein.

Cheng Z, et al. (2004 Jan 9). RNA branching and debranching in the yeast retrovirus-like element Ty1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%