FOG13847
EOG8H18CK

sce:SHO1

Genes: 30

SGD Description
Transmembrane osmosensor for filamentous growth and HOG pathways; involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol (HOG) response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p


AspGD Description
Ortholog(s) have MAP-kinase scaffold activity, osmosensor activity


References

Maeda T, et al. (1995 Jul 28). Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.

Posas F, et al. (1997 Jun 13). Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.

O'Rourke SM, et al. (1998 Sep 15). The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae.

Siderius M, et al. (2000 Dec 15). Candidate osmosensors from Candida utilis and Kluyveromyces lactis: structural and functional homology to the Sho1p putative osmosensor from Saccharomyces cerevisiae.

Van Wuytswinkel O, et al. (2000 Jul). Response of Saccharomyces cerevisiae to severe osmotic stress: evidence for a novel activation mechanism of the HOG MAP kinase pathway.

García-Rodriguez LJ, et al. (2000 May). Calcofluor antifungal action depends on chitin and a functional high-osmolarity glycerol response (HOG) pathway: evidence for a physiological role of the Saccharomyces cerevisiae HOG pathway under noninducing conditions.

Singh KK, et al. (2000 Nov 15). The Saccharomyces cerevisiae Sln1p-Ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion.

Reiser V, et al. (2000 Sep). Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42.

Raitt DC, et al. (2000 Sep 1). Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway.

Toh-e A, et al. (2001 Dec). Defects in glycosylphosphatidylinositol (GPI) anchor synthesis activate Hog1 kinase and confer copper-resistance in Saccharomyces cerevisisae.

Winkler A, et al. (2002 Apr). Heat stress activates the yeast high-osmolarity glycerol mitogen-activated protein kinase pathway, and protein tyrosine phosphatases are essential under heat stress.

Bagnat M, et al. (2002 Oct 29). Cell surface polarization during yeast mating.

Zarrinpar A, et al. (2003 Dec 11). Optimization of specificity in a cellular protein interaction network by negative selection.

Park SH, et al. (2003 Feb 14). Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms.

O'Rourke SM, et al. (2004 Feb). Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.

Nelson B, et al. (2004 Jan). Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating.

Cullen PJ, et al. (2004 Jul 15). A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast.

Marles JA, et al. (2004 Jun 18). Protein-protein interaction affinity plays a crucial role in controlling the Sho1p-mediated signal transduction pathway in yeast.

Zarrinpar A, et al. (2004 Jun 18). Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway.

Román E, et al. (2005 Dec). The Sho1 adaptor protein links oxidative stress to morphogenesis and cell wall biosynthesis in the fungal pathogen Candida albicans.

Furukawa K, et al. (2005 Jun). Aspergillus nidulans HOG pathway is activated only by two-component signalling pathway in response to osmotic stress.

Liu TT, et al. (2005 Jun). Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Tatebayashi K, et al. (2006 Jul 12). Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Hao N, et al. (2007 Apr 17). A systems-biology analysis of feedback inhibition in the Sho1 osmotic-stress-response pathway.

Gregori C, et al. (2007 Sep). The high-osmolarity glycerol response pathway in the human fungal pathogen Candida glabrata strain ATCC 2001 lacks a signaling branch that operates in baker's yeast.

Hersen P, et al. (2008 May 20). Signal processing by the HOG MAP kinase pathway.

Román E, et al. (2009 Aug). Msb2 signaling mucin controls activation of Cek1 mitogen-activated protein kinase in Candida albicans.

Pitoniak A, et al. (2009 Jul). The signaling mucins Msb2 and Hkr1 differentially regulate the filamentation mitogen-activated protein kinase pathway and contribute to a multimodal response.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Miskei M, et al. (2009 Mar). Annotation of stress-response proteins in the aspergilli.

Macia J, et al. (2009 Mar 24). Dynamic signaling in the Hog1 MAPK pathway relies on high basal signal transduction.

Li D, et al. (2009 Oct). The Candida albicans histidine kinase Chk1p: signaling and cell wall mannan.

Román E, et al. (2009 Sep). The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogen Candida albicans.

Reijnst P, et al. (2010 Jun). Functional analysis of Candida albicans genes encoding SH3-domain-containing proteins.

Zucchi PC, et al. (2010 May). A Candida albicans cell wall-linked protein promotes invasive filamentation into semi-solid medium.

Cantero PD, et al. (2011 May). Damage to the glycoshield activates PMT-directed O-mannosylation via the Msb2-Cek1 pathway in Candida albicans.

Ravin NV, et al. (2013 Nov 27). Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha DL1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 29 genes with posterior transmembrane prediction > 50%