FOG13666
EOG8HHMHC

sce:GRR1

Genes: 33

SGD Description
F-box protein component of an SCF ubiquitin-ligase complex; modular substrate specificity factor which associates with core SCF (Cdc53p, Skp1p and Hrt1p/Rbx1p) to form the SCF(Grr1) complex; SCF(Grr1) acts as a ubiquitin-protein ligase directing ubiquitination of substrates such as: Gic2p, Mks1p, Mth1p, Cln1p, Cln2p and Cln3p; involved in carbon catabolite repression, glucose-dependent divalent cation transport, glucose transport, morphogenesis, and sulfite detoxification


PomBase Description
F-box protein Pof2


AspGD Description
Ortholog(s) have role in G1/S transition of mitotic cell cycle, ascospore formation, pseudohyphal growth and SCF ubiquitin ligase complex, mitochondrion localization


References

Flick JS, et al. (1991 Oct). GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats.

Barral Y, et al. (1995 Feb 15). G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast.

Jaquenoud M, et al. (1998 Sep 15). The Cdc42p effector Gic2p is targeted for ubiquitin-dependent degradation by the SCFGrr1 complex.

Skowyra D, et al. (1999 Apr 23). Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1.

Kus BM, et al. (2004 Feb 15). Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro.

Lehmann A, et al. (2004 May). Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.

Krappmann S, et al. (2006 Jul). The Aspergillus nidulans F-box protein GrrA links SCF activity to meiosis.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Colabardini AC, et al. (2012 Feb). Molecular characterization of the Aspergillus nidulans fbxA encoding an F-box protein involved in xylanase induction.

Leach MD, et al. (2012 Feb). Posttranslational modifications of proteins in the pathobiology of medically relevant fungi.

Bayram O, et al. (2012 Jan). Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins.

Dyer PS, et al. (2012 Jan). Sexual development and cryptic sexuality in fungi: insights from Aspergillus species.

von Zeska Kress MR, et al. (2012 Mar). The COP9 signalosome counteracts the accumulation of cullin SCF ubiquitin E3 RING ligases during fungal development.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%