FOG13580
EOG8HQC35

sce:END3

Genes: 32

SGD Description
EH domain-containing protein involved in endocytosis; actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p


PomBase Description
actin cortical patch component End3 (predicted)


AspGD Description
Ortholog(s) have role in cellular response to DNA damage stimulus


References

Swirski RA, et al. (1988 May). Repair of alkylation damage in the fungus Aspergillus nidulans.

Raths S, et al. (1993 Jan). end3 and end4: two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae.

Volland C, et al. (1994 Apr 1). Endocytosis and degradation of the yeast uracil permease under adverse conditions.

Berkower C, et al. (1994 Nov). Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae.

Bénédetti H, et al. (1994 Sep). The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast.

Lai K, et al. (1995 Feb 10). Regulation of inositol transport in Saccharomyces cerevisiae involves inositol-induced changes in permease stability and endocytic degradation in the vacuole.

Tan PK, et al. (1996 Dec). The sequence NPFXD defines a new class of endocytosis signal in Saccharomyces cerevisiae.

Robinson KS, et al. (1996 Jan). Inositol transport in Saccharomyces cerevisiae is regulated by transcriptional and degradative endocytic mechanisms during the growth cycle that are distinct from inositol-induced regulation.

Ayscough KR, et al. (1997 Apr 21). High rates of actin filament turnover in budding yeast and roles for actin in establishment and maintenance of cell polarity revealed using the actin inhibitor latrunculin-A.

Tang HY, et al. (1997 Aug). EH domain proteins Pan1p and End3p are components of a complex that plays a dual role in organization of the cortical actin cytoskeleton and endocytosis in Saccharomyces cerevisiae.

Moreau V, et al. (1997 Jul). The yeast actin-related protein Arp2p is required for the internalization step of endocytosis.

Prescianotto-Baschong C, et al. (1998 Jan). Morphology of the yeast endocytic pathway.

Paoluzi S, et al. (1998 Nov 16). Recognition specificity of individual EH domains of mammals and yeast.

Zeng G, et al. (1999 Jan 11). Regulation of the actin cytoskeleton organization in yeast by a novel serine/threonine kinase Prk1p.

Jones GW, et al. (1999 Mar). Cloning and characterisation of the sagA gene of Aspergillus nidulans: a gene which affects sensitivity to DNA-damaging agents.

Eisfeld K, et al. (2000 Aug). Endocytotic uptake and retrograde transport of a virally encoded killer toxin in yeast.

Tang HY, et al. (2000 Jan). Pan1p, End3p, and S1a1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis.

Gagny B, et al. (2000 Sep). A novel EH domain protein of Saccharomyces cerevisiae, Ede1p, involved in endocytosis.

Zeng G, et al. (2001 Dec). Regulation of yeast actin cytoskeleton-regulatory complex Pan1p/Sla1p/End3p by serine/threonine kinase Prk1p.

Howard JP, et al. (2002 Apr 15). Sla1p serves as the targeting signal recognition factor for NPFX(1,2)D-mediated endocytosis.

Steinmetz LM, et al. (2002 Mar 21). Dissecting the architecture of a quantitative trait locus in yeast.

Yin Z, et al. (2004 Aug). Proteomic response to amino acid starvation in Candida albicans and Saccharomyces cerevisiae.

Aouida M, et al. (2004 Nov 15). Characterization of a transport and detoxification pathway for the antitumour drug bleomycin in Saccharomyces cerevisiae.

Morishita M, et al. (2005 Aug). End3p-mediated endocytosis is required for spore wall formation in Saccharomyces cerevisiae.

Deutschbauer AM, et al. (2005 Dec). Quantitative trait loci mapped to single-nucleotide resolution in yeast.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Gourlay CW, et al. (2006 Sep). Actin-induced hyperactivation of the Ras signaling pathway leads to apoptosis in Saccharomyces cerevisiae.

Zeng G, et al. (2007 Dec). Scd5p mediates phosphoregulation of actin and endocytosis by the type 1 phosphatase Glc7p in yeast.

Toshima J, et al. (2007 Feb). Negative regulation of yeast Eps15-like Arp2/3 complex activator, Pan1p, by the Hip1R-related protein, Sla2p, during endocytosis.

Toret CP, et al. (2008 May). Multiple pathways regulate endocytic coat disassembly in Saccharomyces cerevisiae for optimal downstream trafficking.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Nützmann HW, et al. (2011 Aug 23). Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Karachaliou M, et al. (2013 Apr). The arrestin-like protein ArtA is essential for ubiquitination and endocytosis of the UapA transporter in response to both broad-range and specific signals.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Cánovas D, et al. (2014 Aug). The histone acetyltransferase GcnE (GCN5) plays a central role in the regulation of Aspergillus asexual development.

Lucena-Agell D, et al. (2015 Jun). Aspergillus nidulans Ambient pH Signaling Does Not Require Endocytosis.

Chen JS, et al. (2016 Sep). Discovery of genes involved in mitosis, cell division, cell wall integrity and chromosome segregation through construction of Schizosaccharomyces pombe deletion strains.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%