FOG13521
EOG8HT7CC

sce:DSN1

Genes: 5

SGD Description
Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; phosphorylation of Dsn1p promotes interaction between outer and inner kinetochore proteins; N-terminal end interacts with monopolin subunit Csm1p and is essential for meiotic but not mitotic chromosome segregation; important for chromosome segregation; complex consists of Mtw1p Including Nnf1p-Nsl1p-Dsn1p (MIND); modified by sumoylation


References

Guiard B, et al. (1976). Complete amino acid sequence of the heme-binding core in bakers' yeast cytochrome b2 (L-(+)-lactate dehydrogenase).

Euskirchen GM, et al. (2002 Apr). Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae.

De Wulf P, et al. (2003 Dec 1). Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes.

Scharfenberger M, et al. (2003 Dec 15). Nsl1p is essential for the establishment of bipolarity and the localization of the Dam-Duo complex.

Pinsky BA, et al. (2003 Nov). An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase.

Dimitrova YN, et al. (2016 Nov 3). Structure of the MIND Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%