FOG13416
EOG8J3V02

sce:SSZ1

Genes: 35

SGD Description
Hsp70 protein that interacts with Zuo1p (a DnaJ homolog); interacts with Zuo1p to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP


PomBase Description
heat shock protein Ssz1 (predicted)


AspGD Description
Ortholog(s) have unfolded protein binding activity, role in cytoplasmic translation, rRNA processing, regulation of translational fidelity, translational frameshifting and cell surface, cytosol, nucleus, polysome localization


References

Shevchenko A, et al. (1996 Dec 10). Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels.

Michimoto T, et al. (2000 Oct 17). Yeast Pdr13p and Zuo1p molecular chaperones are new functional Hsp70 and Hsp40 partners.

Gautschi M, et al. (2001 Mar 27). RAC, a stable ribosome-associated complex in yeast formed by the DnaK-DnaJ homologs Ssz1p and zuotin.

Hundley H, et al. (2002 Apr 2). The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Rakwalska M, et al. (2004 Oct). The ribosome-bound chaperones RAC and Ssb1/2p are required for accurate translation in Saccharomyces cerevisiae.

Huang P, et al. (2005 Jun). The Hsp70 Ssz1 modulates the function of the ribosome-associated J-protein Zuo1.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Wartenberg D, et al. (2012 Jul 16). Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%