FOG13391
EOG8J3V2J

sce:UFD1

Genes: 33

SGD Description
Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transaction factors by regulated Ub/proteasome-dependent processing (RUP)


PomBase Description
Cdc48-Ufd1-Npl4 complex subunit Ufd1 involved in ubiquitin-dependent protein catabolism (predicted)


AspGD Description
Ortholog(s) have polyubiquitin binding activity


References

Johnson ES, et al. (1995 Jul 21). A proteolytic pathway that recognizes ubiquitin as a degradation signal.

del Olmo M, et al. (1997 Jun). The Uba2 and Ufd1 proteins of Saccharomyces cerevisiae interact with poly(A) polymerase and affect the polyadenylation activity of cell extracts.

Ye Y, et al. (2001 Dec 6). The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.

Rape M, et al. (2001 Nov 30). Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone.

Hitchcock AL, et al. (2001 Oct). The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation.

Braun S, et al. (2002 Feb 15). Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates.

Deutschbauer AM, et al. (2005 Dec). Quantitative trait loci mapped to single-nucleotide resolution in yeast.

Park S, et al. (2005 Jul). Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin interaction sites.

Carvalho P, et al. (2006 Jul 28). Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%