FOG13362
EOG8J6Q7H

sce:RPN6

Genes: 33

SGD Description
Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress


PomBase Description
19S proteasome regulatory subunit Rpn6 (predicted)


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Saito A, et al. (1997 Dec 12). cDNA cloning and functional analysis of p44.5 and p55, two regulatory subunits of the 26S proteasome.

Taricani L, et al. (2002 Mar 22). The fission yeast ES2 homologue, Bis1, interacts with the Ish1 stress-responsive nuclear envelope protein.

Santamaria PG, et al. (2003 Feb 28). Rpn6p, a proteasome subunit from Saccharomyces cerevisiae, is essential for the assembly and activity of the 26 S proteasome.

Kimura Y, et al. (2003 Jan 15). N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome.

Isono E, et al. (2005 Feb 25). Functional analysis of Rpn6p, a lid component of the 26 S proteasome, using temperature-sensitive rpn6 mutants of the yeast Saccharomyces cerevisiae.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Bohn S, et al. (2010 Dec 7). Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution.

Takeda K, et al. (2010 Feb 23). Synergistic roles of the proteasome and autophagy for mitochondrial maintenance and chronological lifespan in fission yeast.

Selvanathan SP, et al. (2010 May 7). Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks.

Kouranti I, et al. (2010 Sep 7). A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Singh NS, et al. (2011 Dec 6). SIN-inhibitory phosphatase complex promotes Cdc11p dephosphorylation and propagates SIN asymmetry in fission yeast.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Pathare GR, et al. (2012 Jan 3). The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together.

Lasker K, et al. (2012 Jan 31). Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Beck F, et al. (2012 Sep 11). Near-atomic resolution structural model of the yeast 26S proteasome.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%