FOG13322
EOG8J9KHW

sce:CLN3

Genes: 16

SGD Description
G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote G1 to S phase transition; plays a role in regulating transcription of other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis; acetly-CoA induces CLN3 transcription in response to nutrient repletion to promote cell-cycle entry


References

Nash R, et al. (1988 Dec 20). The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog.

Cross FR, et al. (1988 Nov). DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae.

Sherlock G, et al. (1994 Dec 15). Molecular cloning and analysis of CDC28 and cyclin homologues from the human fungal pathogen Candida albicans.

Bachewich C, et al. (2005 Jan). Cyclin Cln3p links G1 progression to hyphal and pseudohyphal development in Candida albicans.

Chapa y Lazo B, et al. (2005 Jan). The G1 cyclin Cln3 regulates morphogenesis in Candida albicans.

Enjalbert B, et al. (2005 Jul). Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth.

Li WJ, et al. (2006 Oct). The F-box protein Grr1 regulates the stability of Ccn1, Cln3 and Hof1 and cell morphogenesis in Candida albicans.

Sinha I, et al. (2007 Sep). Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development.

Zeng G, et al. (2012 Sep). Cdc28-Cln3 phosphorylation of Sla1 regulates actin patch dynamics in different modes of fungal growth.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 8 genes with posterior transmembrane prediction > 50%