FOG13198
EOG8JQ2DD

sce:SEC63

Genes: 33

SGD Description
Essential subunit of Sec63 complex; with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER; other members are Sec62p, Sec66p, and Sec72p


PomBase Description
ER protein translocation subcomplex subunit Sec63 (predicted)


AspGD Description
Putative SEC63 complex subunit; expression enhanced by maltose; expression induced by tunicamycin and DTT


References

Sadler I, et al. (1989 Dec). A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein.

Deshaies RJ, et al. (1991 Feb 28). Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex.

Feldheim D, et al. (1992 Jul). Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation.

Brodsky JL, et al. (1993 Dec). A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome.

Nelson MK, et al. (1993 May). Extragenic suppressors of mutations in the cytoplasmic C terminus of SEC63 define five genes in Saccharomyces cerevisiae.

Panzner S, et al. (1995 May 19). Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p.

Young BP, et al. (2001 Jan 15). Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo.

Willer M, et al. (2003 Jan 30). Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane.

Wang X, et al. (2005 Feb 15). Protein kinase CK2 phosphorylates Sec63p to stimulate the assembly of the endoplasmic reticulum protein translocation apparatus.

Sims AH, et al. (2005 May). Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded-protein response in vivo.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Vjestica A, et al. (2008 Mar). The actomyosin ring recruits early secretory compartments to the division site in fission yeast.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Ryuko S, et al. (2012 Aug). Genome-wide screen reveals novel mechanisms for regulating cobalt uptake and detoxification in fission yeast.

Markina-Iñarrairaegui A, et al. (2013). The Aspergillus nidulans peripheral ER: disorganization by ER stress and persistence during mitosis.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 33 genes with posterior transmembrane prediction > 50%