FOG13073
EOG8K0P54

sce:TRM10

Genes: 34

SGD Description
tRNA methyltransferase; methylates the N-1 position of guanine at position 9 in tRNAs; protein abundance increases in response to DNA replication stress; member of the SPOUT (SpoU-TrmD) methyltransferase family; human ortholog TRMT10A plays a role in the pathogenesis of microcephaly and early onset diabetes; an 18-mer originates from the TRM10 locus; genetic analysis shows the 18-mer is the translation regulator


PomBase Description
tRNA m(1)G methyltransferase Trm10


AspGD Description
Ortholog(s) have tRNA (guanine(9)-N(1))-methyltransferase activity, role in tRNA N1-guanine methylation and cytoplasm, nucleolus localization


References

Jackman JE, et al. (2003 May). Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9.

Hiley SL, et al. (2005 Jan 7). Detection and discovery of RNA modifications using microarrays.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Swinehart WE, et al. (2013 Aug). Unexpected expansion of tRNA substrate recognition by the yeast m1G9 methyltransferase Trm10.

Shao Z, et al. (2014 Jan). Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%