FOG13031
EOG8K3JCJ

sce:CLN1;CLN2

Genes: 21

SGD Description
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN1 has a paralog, CLN2, that arose from the whole genome duplication|G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p); CLN2 has a paralog, CLN1, that arose from the whole genome duplication


References

Hadwiger JA, et al. (1989 Aug). A family of cyclin homologs that control the G1 phase in yeast.

Hadwiger JA, et al. (1990 Jul 11). Nucleotide sequence of the Saccharomyces cerevisiae CLN1 and CLN2 genes.

Zheng X, et al. (2004 Apr 21). Hgc1, a novel hypha-specific G1 cyclin-related protein regulates Candida albicans hyphal morphogenesis.

Chapa y Lazo B, et al. (2005 Jan). The G1 cyclin Cln3 regulates morphogenesis in Candida albicans.

Enjalbert B, et al. (2005 Jul). Release from quorum-sensing molecules triggers hyphal formation during Candida albicans resumption of growth.

Hanaoka N, et al. (2005 Jul). A putative dual-specific protein phosphatase encoded by YVH1 controls growth, filamentation and virulence in Candida albicans.

Bassilana M, et al. (2005 Mar). Regulation of the Cdc42/Cdc24 GTPase module during Candida albicans hyphal growth.

Cao F, et al. (2006 Jan). The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans.

Andaluz E, et al. (2006 Mar). Rad52 depletion in Candida albicans triggers both the DNA-damage checkpoint and filamentation accompanied by but independent of expression of hypha-specific genes.

Kaneko A, et al. (2006 Nov). Tcc1p, a novel protein containing the tetratricopeptide repeat motif, interacts with Tup1p to regulate morphological transition and virulence in Candida albicans.

Zheng XD, et al. (2007 Aug 22). Phosphorylation of Rga2, a Cdc42 GAP, by CDK/Hgc1 is crucial for Candida albicans hyphal growth.

Wang A, et al. (2007 Feb). Temporal and spatial control of HGC1 expression results in Hgc1 localization to the apical cells of hyphae in Candida albicans.

Sinha I, et al. (2007 Sep). Cyclin-dependent kinases control septin phosphorylation in Candida albicans hyphal development.

González-Novo A, et al. (2008 Apr). Sep7 is essential to modify septin ring dynamics and inhibit cell separation during Candida albicans hyphal growth.

Wang A, et al. (2009 Aug). Hyphal chain formation in Candida albicans: Cdc28-Hgc1 phosphorylation of Efg1 represses cell separation genes.

Zeidler U, et al. (2009 Feb). UME6 is a crucial downstream target of other transcriptional regulators of true hyphal development in Candida albicans.

Wilson D, et al. (2010 Feb). Hgc1 mediates dynamic Candida albicans-endothelium adhesion events during circulation.

Carlisle PL, et al. (2010 Sep). Candida albicans Ume6, a filament-specific transcriptional regulator, directs hyphal growth via a pathway involving Hgc1 cyclin-related protein.

Bishop A, et al. (2010 Sep 1). Hyphal growth in Candida albicans requires the phosphorylation of Sec2 by the Cdc28-Ccn1/Hgc1 kinase.

Wächtler B, et al. (2011 Feb 23). From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells.

Lin CH, et al. (2013). Genetic control of conventional and pheromone-stimulated biofilm formation in Candida albicans.

Guan G, et al. (2013 Aug). Bcr1 plays a central role in the regulation of opaque cell filamentation in Candida albicans.

Banerjee M, et al. (2013 Feb). Expression of UME6, a key regulator of Candida albicans hyphal development, enhances biofilm formation via Hgc1- and Sun41-dependent mechanisms.

Carlisle PL, et al. (2013 Feb). A genome-wide transcriptional analysis of morphology determination in Candida albicans.

Hsu CC, et al. (2013 Jul). The inhibitory activity of linalool against the filamentous growth and biofilm formation in Candida albicans.

Si H, et al. (2013 Mar). Candida albicans white and opaque cells undergo distinct programs of filamentous growth.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%