FOG12956
EOG8K98T2

sce:REV1

Genes: 33

SGD Description
Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress


PomBase Description
deoxycytidyl transferase Rev1 (predicted)


AspGD Description
Ortholog(s) have role in error-prone translesion synthesis and mitotic spindle, nucleolus, site of double-strand break localization


References

Larimer FW, et al. (1989 Jan). The REV1 gene of Saccharomyces cerevisiae: isolation, sequence, and functional analysis.

Nelson JR, et al. (1996 Aug 22). Deoxycytidyl transferase activity of yeast REV1 protein.

Haracska L, et al. (2001 Apr 15). Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites.

Goldman GH, et al. (2004 Apr). Aspergillus nidulans as a model system to characterize the DNA damage response in eukaryotes.

Nair DT, et al. (2005 Sep 30). Rev1 employs a novel mechanism of DNA synthesis using a protein template.

Zhang H, et al. (2006 Apr). Saccharomyces cerevisiae polymerase zeta functions in mitochondria.

Nair DT, et al. (2008 Feb). Protein-template-directed synthesis across an acrolein-derived DNA adduct by yeast Rev1 DNA polymerase.

Kosarek JN, et al. (2008 Mar 1). Comparative analysis of in vivo interactions between Rev1 protein and other Y-family DNA polymerases in animals and yeasts.

Deshpande GP, et al. (2009 May 1). Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Coulon S, et al. (2010 Jun 16). Rad8Rad5/Mms2-Ubc13 ubiquitin ligase complex controls translesion synthesis in fission yeast.

Callegari AJ, et al. (2010 May 4). Postreplication gaps at UV lesions are signals for checkpoint activation.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Groocock LM, et al. (2012 Jan). The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.

Yu Y, et al. (2013 Jun 1). A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Pietrobon V, et al. (2014 Oct). The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1.

Uchiyama M, et al. (2015). The Protein Level of Rev1, a TLS Polymerase in Fission Yeast, Is Strictly Regulated during the Cell Cycle and after DNA Damage.

Callegari AJ, et al. (2016). Coordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast.

Ranatunga NS, et al. (2016 Oct 13). Characterization of a Novel MMS-Sensitive Allele of Schizosaccharomyces pombe mcm4.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%