FOG12918
EOG8KD525

sce:GCD6

Genes: 33

SGD Description
Catalytic epsilon subunit of the translation initiation factor eIF2B; eIF2B is the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression; forms cytoplasmic foci upon DNA replication stress


PomBase Description
translation initiation factor eIF2B epsilon subunit (predicted)


AspGD Description
Ortholog(s) have cytosol localization


References

Cigan AM, et al. (1993 Jun 1). A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast.

Bushman JL, et al. (1993 Mar). Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.

Favre B, et al. (1997 Apr 11). Cloning and expression of squalene epoxidase from the pathogenic yeast Candida albicans.

Pavitt GD, et al. (1998 Feb 15). eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

Asano K, et al. (1999 Mar 15). Conserved bipartite motifs in yeast eIF5 and eIF2Bepsilon, GTPase-activating and GDP-GTP exchange factors in translation initiation, mediate binding to their common substrate eIF2.

Gomez E, et al. (2000 Jun). Identification of domains and residues within the epsilon subunit of eukaryotic translation initiation factor 2B (eIF2Bepsilon) required for guanine nucleotide exchange reveals a novel activation function promoted by eIF2B complex formation.

Boesen T, et al. (2004 Mar 12). Structure of the catalytic fragment of translation initiation factor 2B and identification of a critically important catalytic residue.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%