FOG12906
EOG8KD537

sce:CDC14

Genes: 33

SGD Description
Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, and environmental stress response; maintained in nucleolus by Cdc55p in early meiosis until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to effect a decrease in CDK/B-cyclin activity and mitotic exit; sequestered in metaphase II, then released again upon entry into anaphase II


PomBase Description
Cdc14-related protein phosphatase Clp1/Flp1


AspGD Description
Ortholog(s) have protein serine/threonine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity


References

Schild D, et al. (1980 Dec). Diploid spore formation and other meiotic effects of two cell-division-cycle mutations of Saccharomyces cerevisiae.

Wan J, et al. (1992 Jun 5). CDC14 of Saccharomyces cerevisiae. Cloning, sequence analysis, and transcription during the cell cycle.

Shirayama M, et al. (1996 May 23). Dominant mutant alleles of yeast protein kinase gene CDC15 suppress the lte1 defect in termination of M phase and genetically interact with CDC14.

Taylor GS, et al. (1997 Sep 19). The activity of Cdc14p, an oligomeric dual specificity protein phosphatase from Saccharomyces cerevisiae, is required for cell cycle progression.

Visintin R, et al. (1998 Dec). The phosphatase Cdc14 triggers mitotic exit by reversal of Cdk-dependent phosphorylation.

Shou W, et al. (2001 Jul). Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit.

Jiménez J, et al. (2001 Jun 30). A single-copy suppressor of the Saccharomyces cerevisae late-mitotic mutants cdc15 and dbf2 is encoded by the Candida albicans CDC14 gene.

Marston AL, et al. (2003 May). The Cdc14 phosphatase and the FEAR network control meiotic spindle disassembly and chromosome segregation.

Torres-Rosell J, et al. (2004 Apr). Nucleolar segregation lags behind the rest of the genome and requires Cdc14p activation by the FEAR network.

Wang BD, et al. (2004 Jul). Cdc14p/FEAR pathway controls segregation of nucleolus in S. cerevisiae by facilitating condensin targeting to rDNA chromatin in anaphase.

Wang WQ, et al. (2004 Jul 16). Kinetic and mechanistic studies of a cell cycle protein phosphatase Cdc14.

Azzam R, et al. (2004 Jul 23). Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.

Geymonat M, et al. (2004 Mar). Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6.

D'Amours D, et al. (2004 May 14). Cdc14 and condensin control the dissolution of cohesin-independent chromosome linkages at repeated DNA.

Bembenek J, et al. (2005 Jul). Crm1-mediated nuclear export of Cdc14 is required for the completion of cytokinesis in budding yeast.

Clemente-Blanco A, et al. (2006 Mar 15). The Cdc14p phosphatase affects late cell-cycle events and morphogenesis in Candida albicans.

Bloom J, et al. (2007 Feb). Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication.

González-Novo A, et al. (2008 Apr). Sep7 is essential to modify septin ring dynamics and inhibit cell separation during Candida albicans hyphal growth.

Hall MC, et al. (2008 Apr 18). Cdc28 and Cdc14 control stability of the anaphase-promoting complex inhibitor Acm1.

Khmelinskii A, et al. (2008 Feb 1). Assembling the spindle midzone in the right place at the right time.

Geil C, et al. (2008 Jul 8). A nucleolus-localized activator of Cdc14 phosphatase supports rDNA segregation in yeast mitosis.

Rahal R, et al. (2008 Oct). The Polo-like kinase Cdc5 interacts with FEAR network components and Cdc14.

Jwa M, et al. (2008 Sep 22). Regulation of Sli15/INCENP, kinetochore, and Cdc14 phosphatase functions by the ribosome biogenesis protein Utp7.

Mohl DA, et al. (2009 Feb 23). Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis.

Côte P, et al. (2009 Jul). Transcriptional analysis of the Candida albicans cell cycle.

Clemente-Blanco A, et al. (2009 Mar 12). Cdc14 inhibits transcription by RNA polymerase I during anaphase.

Chiroli E, et al. (2009 May). Cdc14 inhibition by the spindle assembly checkpoint prevents unscheduled centrosome separation in budding yeast.

Mirchenko L, et al. (2010 Aug 10). Sli15(INCENP) dephosphorylation prevents mitotic checkpoint reengagement due to loss of tension at anaphase onset.

Akiyoshi B, et al. (2010 Dec). Cdc14-dependent dephosphorylation of a kinetochore protein prior to anaphase in Saccharomyces cerevisiae.

Manzoni R, et al. (2010 Jul 26). Oscillations in Cdc14 release and sequestration reveal a circuit underlying mitotic exit.

Zhai Y, et al. (2010 Nov 15). Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast.

Rossio V, et al. (2010 Nov 29). The RSC chromatin-remodeling complex influences mitotic exit and adaptation to the spindle assembly checkpoint by controlling the Cdc14 phosphatase.

Bloom J, et al. (2011 Feb 18). Global analysis of Cdc14 phosphatase reveals diverse roles in mitotic processes.

Bizzari F, et al. (2011 Jun 27). Cdc55 coordinates spindle assembly and chromosome disjunction during meiosis.

Kerr GW, et al. (2011 Jun 27). Meiotic nuclear divisions in budding yeast require PP2A(Cdc55)-mediated antagonism of Net1 phosphorylation by Cdk.

Bouchoux C, et al. (2011 Nov 11). A quantitative model for ordered Cdk substrate dephosphorylation during mitotic exit.

Tzeng YW, et al. (2011 Oct). Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase.

Quevedo O, et al. (2012). Nondisjunction of a single chromosome leads to breakage and activation of DNA damage checkpoint in G2.

Sanchez-Diaz A, et al. (2012 Aug 29). The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth.

Chin CF, et al. (2012 Jan). Dependence of Chs2 ER export on dephosphorylation by cytoplasmic Cdc14 ensures that septum formation follows mitosis.

Bremmer SC, et al. (2012 Jan 13). Cdc14 phosphatases preferentially dephosphorylate a subset of cyclin-dependent kinase (Cdk) sites containing phosphoserine.

Palani S, et al. (2012 Jul 1). Cdc14-dependent dephosphorylation of Inn1 contributes to Inn1-Cyk3 complex formation.

Faust AM, et al. (2013). The FEAR protein Slk19 restricts Cdc14 phosphatase to the nucleus until the end of anaphase, regulating its participation in mitotic exit in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%