FOG12765
EOG8KPRW4

sce:absent

Genes: 4

PomBase Description
Swi five-dependent recombination mediator Sfr1|Swi5 complex subunit Swi2


AspGD Description
Ortholog(s) have role in double-strand break repair via homologous recombination, intra-S DNA damage checkpoint, positive regulation of DNA binding, strand invasion and Swi5-Sfr1 complex, cytosol, site of double-strand break localization


References

Egel R, et al. (1984 Jun). Genes required for initiation and resolution steps of mating-type switching in fission yeast.

Gutz H, et al. (1985). Switching genes in Schizosaccharomyces pombe.

Lino Y, et al. (1985). Mutants of Schizosaccharomyces pombe which sporulate in the haploid state.

Singh J, et al. (1998 Sep). A novel function of the DNA repair gene rhp6 in mating-type silencing by chromatin remodeling in fission yeast.

Akamatsu Y, et al. (2003 Dec 23). Two different Swi5-containing protein complexes are involved in mating-type switching and recombination repair in fission yeast.

Jia S, et al. (2004 Nov 12). Heterochromatin regulates cell type-specific long-range chromatin interactions essential for directed recombination.

Salakhova AF, et al. (2005 Jun). [The dds20+ gene controls a novel Rad51Sp-dependent pathway of recombinational repair in Schizosaccharomyces pombe].

Martín-Castellanos C, et al. (2005 Nov 22). A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events.

Chikashige Y, et al. (2006 Apr 7). Meiotic proteins bqt1 and bqt2 tether telomeres to form the bouquet arrangement of chromosomes.

Haruta N, et al. (2006 Sep). The Swi5-Sfr1 complex stimulates Rhp51/Rad51- and Dmc1-mediated DNA strand exchange in vitro.

Akamatsu Y, et al. (2007 Mar 7). Fission yeast Swi5/Sfr1 and Rhp55/Rhp57 differentially regulate Rhp51-dependent recombination outcomes.

Aguilar-Arnal L, et al. (2008 Apr 9). The fission yeast homologue of CENP-B, Abp1, regulates directionality of mating-type switching.

Ansbach AB, et al. (2008 Feb). RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe.

Gerber HB, et al. (2008 Jan 30). The CDK-activating kinase (CAK) Csk1 is required for normal levels of homologous recombination and resistance to DNA damage in fission yeast.

Khasanov FK, et al. (2008 Oct). Genetic analysis reveals different roles of Schizosaccharomyces pombe sfr1/dds20 in meiotic and mitotic DNA recombination and repair.

Willis N, et al. (2009 Feb). Mus81, Rhp51(Rad51), and Rqh1 form an epistatic pathway required for the S-phase DNA damage checkpoint.

Dziadkowiec D, et al. (2009 May 1). The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe.

Willis N, et al. (2010 Apr). The fission yeast Rad32(Mre11)-Rad50-Nbs1 complex acts both upstream and downstream of checkpoint signaling in the S-phase DNA damage checkpoint.

Liu NN, et al. (2010 Aug). A genome-wide screen for Schizosaccharomyces pombe deletion mutants that affect telomere length.

Kuwabara N, et al. (2010 Sep 1). Expression, purification and crystallization of Swi5 and the Swi5-Sfr1 complex from fission yeast.

Cavero S, et al. (2010 Sep 23). Critical functions of Rpa3/Ssb3 in S-phase DNA damage responses in fission yeast.

Kokabu Y, et al. (2011 Dec 16). Fission yeast Swi5-Sfr1 protein complex, an activator of Rad51 recombinase, forms an extremely elongated dogleg-shaped structure.

Vejrup-Hansen R, et al. (2011 Mar 7). Schizosaccharomyces pombe Mms1 channels repair of perturbed replication into Rhp51 independent homologous recombination.

Lorenz A, et al. (2012 Jun 22). The fission yeast FANCM ortholog directs non-crossover recombination during meiosis.

Kuwabara N, et al. (2012 Mar 7). Mechanistic insights into the activation of Rad51-mediated strand exchange from the structure of a recombination activator, the Swi5-Sfr1 complex.

Yu Y, et al. (2013 Jun 1). A proteome-wide visual screen identifies fission yeast proteins localizing to DNA double-strand breaks.

Saikusa K, et al. (2013 Mar 7). Characterisation of an intrinsically disordered protein complex of Swi5-Sfr1 by ion mobility mass spectrometry and small-angle X-ray scattering.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Murayama Y, et al. (2013 Nov 1). Dual regulation of Dmc1-driven DNA strand exchange by Swi5-Sfr1 activation and Rad22 inhibition.

Dziadkowiec D, et al. (2013 Sep). Involvement of Schizosaccharomyces pombe rrp1+ and rrp2+ in the Srs2- and Swi5/Sfr1-dependent pathway in response to DNA damage and replication inhibition.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Tsutsui Y, et al. (2014 Aug). Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.

Sideri T, et al. (2014 Dec 1). Parallel profiling of fission yeast deletion mutants for proliferation and for lifespan during long-term quiescence.

Lorenz A, et al. (2014 Dec 16). Rad51/Dmc1 paralogs and mediators oppose DNA helicases to limit hybrid DNA formation and promote crossovers during meiotic recombination.

Chen JS, et al. (2014 Dec 31). Identification of new players in cell division, DNA damage response, and morphogenesis through construction of Schizosaccharomyces pombe deletion strains.

Guo Y, et al. (2014 Jul). Large scale screening of genetic interaction with sgf73(+) in fission yeast.

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%