FOG12705
EOG8KWH7V

sce:SPT5

Genes: 32

SGD Description
Component of the universally conserved Spt4/5 complex (DSIF complex); the complex has multiple roles in concert with RNA polymerases I and II, including regulation of transcription elongation, RNA processing, quality control, and transcription-coupled DNA repair


PomBase Description
DSIF transcription elongation factor complex subunit Spt5


AspGD Description
Ortholog(s) have DSIF complex localization


References

Swanson MS, et al. (1991 Jun). SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat.

Hartzog GA, et al. (1998 Feb 1). Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae.

Lindstrom DL, et al. (2003 Feb). Dual roles for Spt5 in pre-mRNA processing and transcription elongation revealed by identification of Spt5-associated proteins.

Rondón AG, et al. (2003 Feb 3). Molecular evidence for a positive role of Spt4 in transcription elongation.

Howard SC, et al. (2003 Nov). The Ras/PKA signaling pathway may control RNA polymerase II elongation via the Spt4p/Spt5p complex in Saccharomyces cerevisiae.

Sickmann A, et al. (2003 Nov 11). The proteome of Saccharomyces cerevisiae mitochondria.

Mason PB, et al. (2005 Mar 18). Distinction and relationship between elongation rate and processivity of RNA polymerase II in vivo.

Xiao Y, et al. (2005 Sep). Analysis of a splice array experiment elucidates roles of chromatin elongation factor Spt4-5 in splicing.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Shen Z, et al. (2010 Sep 1). Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%