FOG12620
EOG8M37QN

sce:MOT2

Genes: 33

SGD Description
Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication


PomBase Description
CCR4-Not complex ubiquitin-protein ligase E3 subunit Mot2 (predicted)


AspGD Description
Has domain(s) with predicted nucleic acid binding, nucleotide binding, zinc ion binding activity


References

Leberer E, et al. (1994 Jul 1). Molecular characterization of SIG1, a Saccharomyces cerevisiae gene involved in negative regulation of G-protein-mediated signal transduction.

Collart MA, et al. (1994 Mar 1). NOT1(CDC39), NOT2(CDC36), NOT3, and NOT4 encode a global-negative regulator of transcription that differentially affects TATA-element utilization.

Cade RM, et al. (1994 May). MOT2 encodes a negative regulator of gene expression that affects basal expression of pheromone-responsive genes in Saccharomyces cerevisiae.

Irie K, et al. (1994 May). The yeast MOT2 gene encodes a putative zinc finger protein that serves as a global negative regulator affecting expression of several categories of genes, including mating-pheromone-responsive genes.

Liu HY, et al. (1998 Feb 16). The NOT proteins are part of the CCR4 transcriptional complex and affect gene expression both positively and negatively.

Bai Y, et al. (1999 Oct). The CCR4 and CAF1 proteins of the CCR4-NOT complex are physically and functionally separated from NOT2, NOT4, and NOT5.

Chen J, et al. (2001 Dec 7). Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Ukleja M, et al. (2016 Jan 25). The architecture of the Schizosaccharomyces pombe CCR4-NOT complex.

Sugiyama T, et al. (2016 Mar 3). Enhancer of Rudimentary Cooperates with Conserved RNA-Processing Factors to Promote Meiotic mRNA Decay and Facultative Heterochromatin Assembly.

Stowell JAW, et al. (2016 Nov 15). Reconstitution of Targeted Deadenylation by the Ccr4-Not Complex and the YTH Domain Protein Mmi1.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%