FOG12579
EOG8M640B

sce:NDC1

Genes: 32

SGD Description
Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1


PomBase Description
spindle pole body docking protein Cut11


AspGD Description
Ortholog(s) have protein anchor activity and role in establishment of spindle pole body localization to nuclear envelope, mitotic spindle assembly


References

Winey M, et al. (1993 Aug). NDC1: a nuclear periphery component required for yeast spindle pole body duplication.

Chial HJ, et al. (1998 Dec 28). Saccharomyces cerevisiae Ndc1p is a shared component of nuclear pore complexes and spindle pole bodies.

Uetz P, et al. (2000 Feb 10). A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae.

Rout MP, et al. (2000 Feb 21). The yeast nuclear pore complex: composition, architecture, and transport mechanism.

Ito T, et al. (2001 Apr 10). A comprehensive two-hybrid analysis to explore the yeast protein interactome.

Marelli M, et al. (2001 May 14). A link between the synthesis of nucleoporins and the biogenesis of the nuclear envelope.

Helfant AH, et al. (2002 Feb). Composition of the spindle pole body of Saccharomyces cerevisiae and the proteins involved in its duplication.

Suntharalingam M, et al. (2003 Jun). Peering through the pore: nuclear pore complex structure, assembly, and function.

Lau CK, et al. (2004 Apr). A novel allele of Saccharomyces cerevisiae NDC1 reveals a potential role for the spindle pole body component Ndc1p in nuclear pore assembly.

Araki Y, et al. (2006 Apr). The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.

Osmani AH, et al. (2006 Dec). Systematic deletion and mitotic localization of the nuclear pore complex proteins of Aspergillus nidulans.

Kim H, et al. (2006 Jul 25). A global topology map of the Saccharomyces cerevisiae membrane proteome.

Liu HL, et al. (2009 Jan). The three fungal transmembrane nuclear pore complex proteins of Aspergillus nidulans are dispensable in the presence of an intact An-Nup84-120 complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 31 genes with posterior transmembrane prediction > 50%