FOG12540
EOG8M906B

sce:SMC6

Genes: 33

SGD Description
Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18


PomBase Description
Smc5-6 complex SMC subunit Smc6


AspGD Description
Ortholog(s) have double-stranded DNA-dependent ATPase activity, role in double-strand break repair via homologous recombination and Smc5-Smc6 complex, nucleus localization


References

Labouesse M, et al. (1987 Mar). Three suppressor mutations which cure a mitochondrial RNA maturase deficiency occur at the same codon in the open reading frame of the nuclear NAM2 gene.

Lehmann AR, et al. (1995 Dec). The rad18 gene of Schizosaccharomyces pombe defines a new subgroup of the SMC superfamily involved in DNA repair.

Onoda F, et al. (2004 Apr 1). SMC6 is required for MMS-induced interchromosomal and sister chromatid recombinations in Saccharomyces cerevisiae.

Zhao X, et al. (2005 Mar 29). A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%