FOG12538
EOG8M906H

sce:RGR1

Genes: 30

SGD Description
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation


PomBase Description
mediator complex subunit Med14


AspGD Description
Has domain(s) with predicted RNA polymerase II transcription cofactor activity, role in regulation of transcription from RNA polymerase II promoter and mediator complex localization


References

Sakai A, et al. (1990 Aug). Structure and molecular analysis of RGR1, a gene required for glucose repression of Saccharomyces cerevisiae.

Jiang YW, et al. (1995 May). Genetic and physical interactions between yeast RGR1 and SIN4 in chromatin organization and transcriptional regulation.

Li Y, et al. (1995 Nov 21). Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.

Liu Y, et al. (2001 Mar 9). Yeast nuclear extract contains two major forms of RNA polymerase II mediator complexes.

Davis JA, et al. (2002 Aug). Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction.

Kuras L, et al. (2003 Nov 25). Association of the Mediator complex with enhancers of active genes.

Guglielmi B, et al. (2004). A high resolution protein interaction map of the yeast Mediator complex.

Liu Y, et al. (2004 Feb). Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex.

Bourbon HM, et al. (2004 Jun 4). A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Nair D, et al. (2005 Oct 7). Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription in yeast extracts.

Takagi Y, et al. (2005 Sep 2). Preponderance of free mediator in the yeast Saccharomyces cerevisiae.

Andrau JC, et al. (2006 Apr 21). Genome-wide location of the coactivator mediator: Binding without activation and transient Cdk8 interaction on DNA.

Takagi Y, et al. (2006 Jan 6). Mediator as a general transcription factor.

Baidoobonso SM, et al. (2007 Feb 23). Med19(Rox3) regulates Intermodule interactions in the Saccharomyces cerevisiae mediator complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%