FOG12451
EOG8MGQR6

sce:UBP6

Genes: 32

SGD Description
Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance


PomBase Description
ubiquitin C-terminal hydrolase Ubp6


AspGD Description
Ortholog(s) have ubiquitin-specific protease activity, role in protein deubiquitination and nucleoplasm localization


References

Park KC, et al. (1997 Nov 1). Purification and characterization of UBP6, a new ubiquitin-specific protease in Saccharomyces cerevisiae.

Wyndham AM, et al. (1999 Jun). The Ubp6 family of deubiquitinating enzymes contains a ubiquitin-like domain: SUb.

Layfield R, et al. (1999 Oct 1). Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes.

Verma R, et al. (2000 Oct). Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes.

Leggett DS, et al. (2002 Sep). Multiple associated proteins regulate proteasome structure and function.

Guterman A, et al. (2004 Jan 16). Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome.

Crosas B, et al. (2006 Dec 29). Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.

Hanna J, et al. (2006 Oct 6). Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%