FOG12413
EOG8MKM0B

sce:RRP4

Genes: 33

SGD Description
Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2)


PomBase Description
exosome subunit Rrp4


AspGD Description
Ortholog(s) have cytosol, exosome (RNase complex), mitotic spindle pole body, nucleus localization


References

Mitchell P, et al. (1996 Feb 15). The 3' end of yeast 5.8S rRNA is generated by an exonuclease processing mechanism.

Mitchell P, et al. (1997 Nov 14). The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases.

Allmang C, et al. (1999 Aug 15). The yeast exosome and human PM-Scl are related complexes of 3' --> 5' exonucleases.

Mitchell P, et al. (2003 Oct). Rrp47p is an exosome-associated protein required for the 3' processing of stable RNAs.

Liu Q, et al. (2006 Dec 15). Reconstitution, activities, and structure of the eukaryotic RNA exosome.

Dziembowski A, et al. (2007 Jan). A single subunit, Dis3, is essentially responsible for yeast exosome core activity.

Schaeffer D, et al. (2009 Jan). The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Coy S, et al. (2013). The Sm complex is required for the processing of non-coding RNAs by the exosome.

Malecki M, et al. (2013 Jul 3). The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%