FOG12299
EOG8MW6PC

sce:NUF2

Genes: 30

SGD Description
Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p


PomBase Description
NMS complex subunit Nuf2


AspGD Description
Ortholog(s) have role in attachment of mitotic spindle microtubules to kinetochore and NMS complex, Ndc80 complex, condensed nuclear chromosome kinetochore, meiotic spindle pole body, mitotic spindle pole body localization


References

Osborne MA, et al. (1994 May). Nuf2, a spindle pole body-associated protein required for nuclear division in yeast.

Janke C, et al. (2001 Feb 15). The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control.

Wigge PA, et al. (2001 Jan 22). The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation.

McCleland ML, et al. (2003 Jan 1). The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity.

Kerres A, et al. (2004 Dec). The fission yeast kinetochore component Spc7 associates with the EB1 family member Mal3 and is required for kinetochore-spindle association.

Wei RR, et al. (2005 Apr 12). Molecular organization of the Ndc80 complex, an essential kinetochore component.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%