FOG12296
EOG8MW6PH

sce:MDM10

Genes: 32

SGD Description
Subunit of both the ERMES and the SAM complex; component of ERMES complex which acts as a molecular tether between the mitochondria and the ER, necessary for efficient phospholipid exchange between organelles and for mitophagy; SAM/TOB complex component that functions in the assembly of outer membrane beta-barrel proteins; involved in mitochondrial inheritance and morphology; ERMES complex is often co-localized with peroxisomes and concentrated areas of pyruvate dehydrogenase


PomBase Description
ERMES complex subunit Mdm10 (predicted)


AspGD Description
Ortholog(s) have role in establishment of mitochondrion localization, mitochondrial outer membrane translocase complex assembly, mitochondrion distribution and mitochondrion morphogenesis, more


References

Whyte W, et al. (1990 Oct 30). Molecular cloning of chromosome I DNA from Saccharomyces cerevisiae: isolation, characterization and regulation of the SPO7 sporulation gene.

Clark MW, et al. (1994 Apr). Sequencing of chromosome I of Saccharomyces cerevisiae: analysis of the 42 kbp SPO7-CENI-CDC15 region.

Sogo LF, et al. (1994 Sep). Regulation of mitochondrial morphology and inheritance by Mdm10p, a protein of the mitochondrial outer membrane.

Berger KH, et al. (1997 Feb 10). Mdm12p, a component required for mitochondrial inheritance that is conserved between budding and fission yeast.

Boldogh I, et al. (1998 Jun 15). Interaction between mitochondria and the actin cytoskeleton in budding yeast requires two integral mitochondrial outer membrane proteins, Mmm1p and Mdm10p.

Hanekamp T, et al. (2002 Nov). Maintenance of mitochondrial morphology is linked to maintenance of the mitochondrial genome in Saccharomyces cerevisiae.

Paschen SA, et al. (2003 Dec 18). Evolutionary conservation of biogenesis of beta-barrel membrane proteins.

Wiedemann N, et al. (2003 Jul 31). Machinery for protein sorting and assembly in the mitochondrial outer membrane.

Boldogh IR, et al. (2003 Nov). A protein complex containing Mdm10p, Mdm12p, and Mmm1p links mitochondrial membranes and DNA to the cytoskeleton-based segregation machinery.

Meisinger C, et al. (2004 Jul). The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane.

Meisinger C, et al. (2006 Aug 11). Mitochondrial protein sorting: differentiation of beta-barrel assembly by Tom7-mediated segregation of Mdm10.

Zahedi RP, et al. (2006 Mar). Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins.

Meisinger C, et al. (2007 May 2). The morphology proteins Mdm12/Mmm1 function in the major beta-barrel assembly pathway of mitochondria.

Kornmann B, et al. (2009 Jul 24). An ER-mitochondria tethering complex revealed by a synthetic biology screen.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%