FOG12222
EOG8N2Z4C

sce:ADA2

Genes: 33

SGD Description
Transcription coactivator; component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes


PomBase Description
SAGA complex subunit Ada2


AspGD Description
Ortholog(s) have chromatin binding, histone acetyltransferase activity, phosphatidylserine binding, sequence-specific DNA binding, transcription coactivator activity


References

Berger SL, et al. (1992 Jul 24). Genetic isolation of ADA2: a potential transcriptional adaptor required for function of certain acidic activation domains.

Marcus GA, et al. (1994 Oct 17). Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors.

Horiuchi J, et al. (1997 Jun). ADA1, a novel component of the ADA/GCN5 complex, has broader effects than GCN5, ADA2, or ADA3.

Grant PA, et al. (1998 Dec). The ATM-related cofactor Tra1 is a component of the purified SAGA complex.

Grant PA, et al. (1998 Jul 10). A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation.

Grant PA, et al. (1999 Feb 26). Expanded lysine acetylation specificity of Gcn5 in native complexes.

Eberharter A, et al. (1999 Oct). The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae.

Pray-Grant MG, et al. (2002 Dec). The novel SLIK histone acetyltransferase complex functions in the yeast retrograde response pathway.

Sterner DE, et al. (2002 Sep 3). SALSA, a variant of yeast SAGA, contains truncated Spt7, which correlates with activated transcription.

Wu PY, et al. (2004 Jul 23). Molecular architecture of the S. cerevisiae SAGA complex.

Pray-Grant MG, et al. (2005 Jan 27). Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.

Bruno VM, et al. (2006 Mar). Control of the C. albicans cell wall damage response by transcriptional regulator Cas5.

Reyes-Dominguez Y, et al. (2008 Apr). Nucleosome positioning and histone H3 acetylation are independent processes in the Aspergillus nidulans prnD-prnB bidirectional promoter.

Sellam A, et al. (2009 May). Genome-wide mapping of the coactivator Ada2p yields insight into the functional roles of SAGA/ADA complex in Candida albicans.

Pukkila-Worley R, et al. (2009 Nov). Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model.

Nützmann HW, et al. (2011 Aug 23). Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation.

Finkel JS, et al. (2012 Feb). Portrait of Candida albicans adherence regulators.

Georgakopoulos P, et al. (2013). The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex in Aspergillus nidulans.

Harting R, et al. (2013 Dec). Interplay of the fungal sumoylation network for control of multicellular development.

Bok JW, et al. (2013 Sep). VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%