FOG12211
EOG8N2Z6F

sce:SIZ1;NFI1

Genes: 33

SGD Description
SUMO/Smt3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring; SIZ1 has a paralog, NFI1, that arose from the whole genome duplication|SUMO E3 ligase; catalyzes sumoylation of Yku70p/Yku80p and Sir4p promoting chromatin anchoring; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; promotes telomere anchoring to the nuclear envelope; involved in maintenance of proper telomere length; NFI1 has a paralog, SIZ1, that arose from the whole genome duplication


PomBase Description
SUMO E3 ligase Pli1


AspGD Description
Ortholog(s) have SUMO ligase activity


References

Ashby MN, et al. (1993 Aug). Isolation and DNA sequence of the STE14 gene encoding farnesyl cysteine: carboxyl methyltransferase.

Takahashi Y, et al. (2001 Dec 28). Yeast Ull1/Siz1 is a novel SUMO1/Smt3 ligase for septin components and functions as an adaptor between conjugating enzyme and substrates.

Strunnikov AV, et al. (2001 May). Saccharomyces cerevisiae SMT4 encodes an evolutionarily conserved protease with a role in chromosome condensation regulation.

Takahashi Y, et al. (2001 Sep 19). A novel factor required for the SUMO1/Smt3 conjugation of yeast septins.

Johnson ES, et al. (2001 Sep 21). An E3-like factor that promotes SUMO conjugation to the yeast septins.

Hoege C, et al. (2002 Sep 12). RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

Takahashi Y, et al. (2003 Apr). Comparative analysis of yeast PIAS-type SUMO ligases in vivo and in vitro.

Zhou W, et al. (2004 Jul 30). Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses.

Takahashi Y, et al. (2005 Oct 28). Yeast PIAS-type Ull1/Siz1 is composed of SUMO ligase and regulatory domains.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Harting R, et al. (2013 Dec). Interplay of the fungal sumoylation network for control of multicellular development.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%