FOG12032
EOG8NK99C

sce:TOR1;TOR2

Genes: 36

SGD Description
PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication|PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication


PomBase Description
phosphatidylinositol kinase Tor1|phosphatidylinositol kinase Tor2


AspGD Description
1-phosphatidylinositol 3-kinase/phosphoinositide 3-kinase


References

Kunz J, et al. (1993 May 7). Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression.

Cafferkey R, et al. (1993 Oct). Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.

Helliwell SB, et al. (1994 Jan). TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast.

Cardenas ME, et al. (1995 Dec 1). FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.

Zheng XF, et al. (1995 Jul 14). TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin.

Barbet NC, et al. (1996 Jan). TOR controls translation initiation and early G1 progression in yeast.

Schmidt A, et al. (1996 Nov 26). TOR2 is required for organization of the actin cytoskeleton in yeast.

Berset C, et al. (1998 Apr 14). The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae.

Schmidt A, et al. (1998 Dec 1). The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease.

Powers T, et al. (1999 Apr). Regulation of ribosome biogenesis by the rapamycin-sensitive TOR-signaling pathway in Saccharomyces cerevisiae.

Alarcon CM, et al. (1999 Aug). Protein kinase activity and identification of a toxic effector domain of the target of rapamycin TOR proteins in yeast.

Beck T, et al. (1999 Dec 9). The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors.

Jiang Y, et al. (1999 May 17). Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.

Kunz J, et al. (2000 Nov 24). HEAT repeats mediate plasma membrane localization of Tor2p in yeast.

Kamada Y, et al. (2000 Sep 18). Tor-mediated induction of autophagy via an Apg1 protein kinase complex.

Jacinto E, et al. (2001 Nov). TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.

Loewith R, et al. (2002 Sep). Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control.

Wedaman KP, et al. (2003 Mar). Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae.

deHart AK, et al. (2003 Nov). Receptor internalization in yeast requires the Tor2-Rho1 signaling pathway.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Martin DE, et al. (2004 Dec 29). TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1.

Audhya A, et al. (2004 Oct 1). Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton.

Fadri M, et al. (2005 Apr). The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2.

Kamada Y, et al. (2005 Aug). Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization.

Dames SA, et al. (2005 May 27). The solution structure of the FATC domain of the protein kinase target of rapamycin suggests a role for redox-dependent structural and cellular stability.

Fitzgibbon GJ, et al. (2005 Sep). Genetic analysis of the TOR pathway in Aspergillus nidulans.

Wullschleger S, et al. (2005 Sep 2). Molecular organization of target of rapamycin complex 2.

Mulet JM, et al. (2006 Nov 3). Mutual antagonism of target of rapamycin and calcineurin signaling.

Urban J, et al. (2007 Jun 8). Sch9 is a major target of TORC1 in Saccharomyces cerevisiae.

De Souza CP, et al. (2013). Functional analysis of the Aspergillus nidulans kinome.

De Souza CP, et al. (2014). Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans.

González A, et al. (2015). TORC1 promotes phosphorylation of ribosomal protein S6 via the AGC kinase Ypk3 in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 22 genes with posterior transmembrane prediction > 50%