FOG12026
EOG8NK9B6

sce:IME4

Genes: 25

SGD Description
mRNA N6-adenosine methyltransferase required for entry into meiosis; mediates N6-adenosine methylation of bulk mRNA during the induction of sporulation which includes the meiotic regulators IME1, IME2 and IME4 itself; repressed in haploids via production of antisense IME4 transcripts; transcribed in diploid cells where antisense transcription is repressed; orthologous to human METTL3 (MT-A70)


References

Shah JC, et al. (1992 Mar). IME4, a gene that mediates MAT and nutritional control of meiosis in Saccharomyces cerevisiae.

Clancy MJ, et al. (2002 Oct 15). Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene.

Agarwala SD, et al. (2012). RNA methylation by the MIS complex regulates a cell fate decision in yeast.

Schwartz S, et al. (2013 Dec 5). High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%