FOG11999
EOG8NP5JG

sce:PEP3

Genes: 33

SGD Description
Component of CORVET membrane tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis


PomBase Description
HOPS/CORVET complex subunit, ubiquitin-protein ligase E3 (predicted)


AspGD Description
Ortholog(s) have role in vacuole organization and cell division site, cytosol localization


References

Preston RA, et al. (1991 Dec). Isolation and characterization of PEP3, a gene required for vacuolar biogenesis in Saccharomyces cerevisiae.

Robinson JS, et al. (1991 Dec). A putative zinc finger protein, Saccharomyces cerevisiae Vps18p, affects late Golgi functions required for vacuolar protein sorting and efficient alpha-factor prohormone maturation.

Srivastava A, et al. (2000 Sep). Pep3p/Pep5p complex: a putative docking factor at multiple steps of vesicular transport to the vacuole of Saccharomyces cerevisiae.

Geissenhöner A, et al. (2001 Dec). Aspergillus nidulans DigA, a potential homolog of Saccharomyces cerevisiae Pep3 (Vps18), is required for nuclear migration, mitochondrial morphology and polarized growth.

Momany M, et al. (2002 Dec). Polarity in filamentous fungi: establishment, maintenance and new axes.

Muthuvijayan V, et al. (2004). In silico reconstruction of nutrient-sensing signal transduction pathways in Aspergillus nidulans.

Stroupe C, et al. (2006 Apr 19). Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.

Harris SD, et al. (2009 Mar). Morphology and development in Aspergillus nidulans: a complex puzzle.

Abenza JF, et al. (2010 Aug 1). Aspergillus RabB Rab5 integrates acquisition of degradative identity with the long distance movement of early endosomes.

Abenza JF, et al. (2012 May). Endosomal maturation by Rab conversion in Aspergillus nidulans is coupled to dynein-mediated basipetal movement.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 6 genes with posterior transmembrane prediction > 50%