FOG11831
EOG8P2NJW

sce:GET3

Genes: 33

SGD Description
Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; functions as a chaperone under ATP-depleted oxidative stress conditions; subunit of the GET complex, which is involved in ATP dependent Golgi to ER trafficking and insertion of tail-anchored (TA) proteins into the ER membrane under non-stress conditions; has low-level ATPase activity; protein abundance increases in response to DNA replication stress


PomBase Description
GET complex ATPase subunit Get3 (predicted)


AspGD Description
Ortholog(s) have cytosol, nucleus localization


References

Ho Y, et al. (2002 Jan 10). Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry.

Shen J, et al. (2003 Sep). The Saccharomyces cerevisiae Arr4p is involved in metal and heat tolerance.

Schuldiner M, et al. (2005 Nov 4). Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

Metz J, et al. (2006 Jan 6). The yeast Arr4p ATPase binds the chloride transporter Gef1p when copper is available in the cytosol.

Auld KL, et al. (2006 Sep). The conserved ATPase Get3/Arr4 modulates the activity of membrane-associated proteins in Saccharomyces cerevisiae.

Schuldiner M, et al. (2008 Aug 22). The GET complex mediates insertion of tail-anchored proteins into the ER membrane.

Hu J, et al. (2009 Nov 30). The crystal structures of yeast Get3 suggest a mechanism for tail-anchored protein membrane insertion.

Suloway CJ, et al. (2009 Sep 1). Model for eukaryotic tail-anchored protein binding based on the structure of Get3.

Mateja A, et al. (2009 Sep 17). The structural basis of tail-anchored membrane protein recognition by Get3.

Yamagata A, et al. (2010 Jan). Structural insight into the membrane insertion of tail-anchored proteins by Get3.

Stewart EV, et al. (2011 Apr 22). Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex.

Mariappan M, et al. (2011 Aug 24). The mechanism of membrane-associated steps in tail-anchored protein insertion.

Stefer S, et al. (2011 Aug 5). Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Kubota K, et al. (2012 Sep 21). Get1 stabilizes an open dimer conformation of get3 ATPase by binding two distinct interfaces.

Das J, et al. (2013 May 21). Cross-species protein interactome mapping reveals species-specific wiring of stress response pathways.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%