FOG11803
EOG8P5HR1

sce:SIN4

Genes: 27

SGD Description
Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription


References

Jiang YW, et al. (1992 Oct). Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae.

Chen S, et al. (1993 Feb). TSF3, a global regulatory protein that silences transcription of yeast GAL genes, also mediates repression by alpha 2 repressor and is identical to SIN4.

Li Y, et al. (1995 Nov 21). Yeast global transcriptional regulators Sin4 and Rgr1 are components of mediator complex/RNA polymerase II holoenzyme.

Davis JA, et al. (2002 Aug). Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction.

Alepuz PM, et al. (2003 May 15). Osmostress-induced transcription by Hot1 depends on a Hog1-mediated recruitment of the RNA Pol II.

Guglielmi B, et al. (2004). A high resolution protein interaction map of the yeast Mediator complex.

Liu Y, et al. (2004 Feb). Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex.

Bourbon HM, et al. (2004 Jun 4). A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

Chibana H, et al. (2005 Aug). Sequence finishing and gene mapping for Candida albicans chromosome 7 and syntenic analysis against the Saccharomyces cerevisiae genome.

van de Peppel J, et al. (2005 Aug 19). Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets.

Nair D, et al. (2005 Oct 7). Mediator and TFIIH govern carboxyl-terminal domain-dependent transcription in yeast extracts.

Takagi Y, et al. (2005 Sep 2). Preponderance of free mediator in the yeast Saccharomyces cerevisiae.

Takagi Y, et al. (2006 Jan 6). Mediator as a general transcription factor.

Baidoobonso SM, et al. (2007 Feb 23). Med19(Rox3) regulates Intermodule interactions in the Saccharomyces cerevisiae mediator complex.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 19 genes with posterior transmembrane prediction > 50%