FOG11778
EOG8P5HV8

sce:SPT15

Genes: 33

SGD Description
TATA-binding protein (TBP); general transcription factor that interacts with other factors to form the preinitiation complex at promoters; essential for viability, highly conserved; yeast gene can complement mutations in human homolog TBP


PomBase Description
TATA-binding protein (TBP)


AspGD Description
Ortholog(s) have DNA binding, bending, RNA polymerase I transcription factor binding and RNA polymerase II activating transcription factor binding, more


References

Cavallini B, et al. (1989 Dec). Cloning of the gene encoding the yeast protein BTF1Y, which can substitute for the human TATA box-binding factor.

Schmidt MC, et al. (1989 Oct). Yeast TATA-box transcription factor gene.

Eisenmann DM, et al. (1989 Sep 22). SPT15, the gene encoding the yeast TATA binding factor TFIID, is required for normal transcription initiation in vivo.

Hahn S, et al. (1989 Sep 22). Isolation of the gene encoding the yeast TATA binding protein TFIID: a gene identical to the SPT15 suppressor of Ty element insertions.

Horikoshi M, et al. (1989 Sep 28). Cloning and structure of a yeast gene encoding a general transcription initiation factor TFIID that binds to the TATA box.

, et al. (1990 Feb 1). Cryptic initiation sequence revealed.

Hoffmann A, et al. (1990 Jul). Cloning of the Schizosaccharomyces pombe TFIID gene reveals a strong conservation of functional domains present in Saccharomyces cerevisiae TFIID.

Fikes JD, et al. (1990 Jul 19). Striking conservation of TFIID in Schizosaccharomyces pombe and Saccharomyces cerevisiae.

Kim Y, et al. (1993 Oct 7). Crystal structure of a yeast TBP/TATA-box complex.

Chasman DI, et al. (1993 Sep 1). Crystal structure of yeast TATA-binding protein and model for interaction with DNA.

Lundgren K, et al. (1996 Jul). A connection between pre-mRNA splicing and the cell cycle in fission yeast: cdc28+ is allelic with prp8+ and encodes an RNA-dependent ATPase/helicase.

Tan S, et al. (1996 May 9). Crystal structure of a yeast TFIIA/TBP/DNA complex.

Kucharski R, et al. (1997 Apr). The TBP gene from Aspergillus nidulans-structure and expression in Saccharomyces cerevisiae.

Chen L, et al. (1997 Apr 15). An immunoaffinity purified Schizosaccharomyces pombe TBP-containing complex directs correct initiation of the S.pombe rRNA gene promoter.

Leng P, et al. (1998 Apr). The TATA-binding protein (TBP) from the human fungal pathogen Candida albicans can complement defects in human and yeast TBPs.

Hampsey M, et al. (1998 Jun). Molecular genetics of the RNA polymerase II general transcriptional machinery.

Liu D, et al. (1998 Sep 4). Solution structure of a TBP-TAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP.

Mitsuzawa H, et al. (2001 May 18). Two WD repeat-containing TATA-binding protein-associated factors in fission yeast that suppress defects in the anaphase-promoting complex.

Maldonado E, et al. (2002). Human papillomavirus-16 E7 protein inhibits the DNA interaction of the TATA binding transcription factor.

Sanders SL, et al. (2002 Aug). Molecular characterization of Saccharomyces cerevisiae TFIID.

Martinez E, et al. (2002 Dec). Multi-protein complexes in eukaryotic gene transcription.

Leurent C, et al. (2002 Jul 1). Mapping histone fold TAFs within yeast TFIID.

Mitsuzawa H, et al. (2002 May 1). Identification of histone H4-like TAF in Schizosaccharomyces pombe as a protein that interacts with WD repeat-containing TAF.

Huang Y, et al. (2003 Apr 15). The fission yeast TFIIB-related factor limits RNA polymerase III to a TATA-dependent pathway of TBP recruitment.

Juo ZS, et al. (2003 Apr 3). Crystal structure of a transcription factor IIIB core interface ternary complex.

Tang Z, et al. (2003 Feb 1). The kic1 kinase of schizosaccharomyces pombe is a CLK/STY orthologue that regulates cell-cell separation.

Kimura M, et al. (2004). Tfg3, a subunit of the general transcription factor TFIIF in Schizosaccharomyces pombe, functions under stress conditions.

Mylona A, et al. (2006 Oct 20). Structure of the tau60/Delta tau91 subcomplex of yeast transcription factor IIIC: insights into preinitiation complex assembly.

Masuo S, et al. (2010 Dec). Global gene expression analysis of Aspergillus nidulans reveals metabolic shift and transcription suppression under hypoxia.

Chinen M, et al. (2010 Feb 19). Involvement of the spliceosomal U4 small nuclear RNA in heterochromatic gene silencing at fission yeast centromeres.

Wendland J, et al. (2011 Dec). Genome evolution in the eremothecium clade of the Saccharomyces complex revealed by comparative genomics.

Pancaldi V, et al. (2012 Apr). Predicting the fission yeast protein interaction network.

Grenier St-Sauveur V, et al. (2013 Dec). Poly(A) tail-mediated gene regulation by opposing roles of Nab2 and Pab2 nuclear poly(A)-binding proteins in pre-mRNA decay.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Lorenzi LE, et al. (2015 Jan 2). Fission yeast Cactin restricts telomere transcription and elongation by controlling Rap1 levels.

Iwasaki O, et al. (2015 Sep 3). Interaction between TBP and Condensin Drives the Organization and Faithful Segregation of Mitotic Chromosomes.

Eckert D, et al. (2016 Jan). Prp4 Kinase Grants the License to Splice: Control of Weak Splice Sites during Spliceosome Activation.

Montes M, et al. (2017 Feb). RNA polymerase II components and Rrn7 form a preinitiation complex on the HomolD box to promote ribosomal protein gene expression in Schizosaccharomyces pombe.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%