FOG11758
EOG8P8D07

sce:HUL5

Genes: 32

SGD Description
Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD; required for ubiquitylation of a subset of cytosolic misfolded proteins upon heat shock


PomBase Description
HECT-type ubiquitin-protein ligase E3 (predicted)


AspGD Description
Ortholog(s) have cytosol, nuclear envelope localization


References

Wang G, et al. (1999 Jan). Functional domains of the Rsp5 ubiquitin-protein ligase.

Boase NA, et al. (2004 Aug). A role for creD, a carbon catabolite repression gene from Aspergillus nidulans, in ubiquitination.

Gatti L, et al. (2011 Jan 19). Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast.

Van Damme P, et al. (2012 Jul 31). N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Kriegenburg F, et al. (2014 Jan). A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 10 genes with posterior transmembrane prediction > 50%