FOG11713
EOG8PC87S

sce:NPR2

Genes: 33

SGD Description
Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human tumor suppressor NPRL2; target of Grr1p; required for growth on urea and proline


PomBase Description
SEA/Iml1/Npr2/3 complex subunit Npr2 (predicted)


AspGD Description
Ortholog(s) have role in cellular response to amino acid starvation, cellular response to nitrogen starvation, negative regulation of TOR signaling, positive regulation of autophagy and proline transport, more


References

Rousselet G, et al. (1995 Feb 13). A second nitrogen permease regulator in Saccharomyces cerevisiae.

Schenk PW, et al. (2003 Aug). Anticancer drug resistance induced by disruption of the Saccharomyces cerevisiae NPR2 gene: a novel component involved in cisplatin- and doxorubicin-provoked cell kill.

Kellis M, et al. (2003 May 15). Sequencing and comparison of yeast species to identify genes and regulatory elements.

Neklesa TK, et al. (2009 Jun). A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex.

Dokudovskaya S, et al. (2011 Jun). A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 4 genes with posterior transmembrane prediction > 50%