FOG11707
EOG8PC88Z

sce:SAS2

Genes: 32

SGD Description
Histone acetyltransferase (HAT) catalytic subunit of the SAS complex; acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family; other members are Sas4p and Sas5p


AspGD Description
Ortholog(s) have histone acetyltransferase activity, role in chromatin silencing at telomere, histone H4 acetylation, histone exchange and SAS acetyltransferase complex, nuclear chromatin localization


References

Reifsnyder C, et al. (1996 Sep). Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases.

Ehrenhofer-Murray AE, et al. (1997 Apr). The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function.

Reifnyder C, et al. (1997 May). Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases.

Meijsing SH, et al. (2001 Dec 1). The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae.

Osada S, et al. (2001 Dec 1). The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1.

Sutton A, et al. (2003 May 9). Sas4 and Sas5 are required for the histone acetyltransferase activity of Sas2 in the SAS complex.

Yuan H, et al. (2012 Jan 4). MYST protein acetyltransferase activity requires active site lysine autoacetylation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%