FOG11651
EOG8PK0Q5

sce:ERB1

Genes: 33

SGD Description
Constituent of 66S pre-ribosomal particles; forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1


PomBase Description
WD repeat/BOP1NT protein Erb1 (predicted)


AspGD Description
Ortholog(s) have large ribosomal subunit rRNA binding activity, role in cellular response to drug, rRNA processing, ribosomal large subunit biogenesis and PeBoW complex, preribosome, large subunit precursor localization


References

Pestov DG, et al. (2001 Sep 1). ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs.

Du YC, et al. (2002 Jun 28). Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication, and ribosome biogenesis.

Miles TD, et al. (2005 Dec). Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes.

Honma Y, et al. (2006 Aug 23). TOR regulates late steps of ribosome maturation in the nucleoplasm via Nog1 in response to nutrients.

Chi A, et al. (2007 Feb 13). Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.

Tang L, et al. (2008 Jul). Interactions among Ytm1, Erb1, and Nop7 required for assembly of the Nop7-subcomplex in yeast preribosomes.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Zhang K, et al. (2011 Mar 25). Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Rhind N, et al. (2011 May 20). Comparative functional genomics of the fission yeasts.

Starita LM, et al. (2012 Jan). Sites of ubiquitin attachment in Saccharomyces cerevisiae.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Wegrecki M, et al. (2015). The carboxy-terminal domain of Erb1 is a seven-bladed ß-propeller that binds RNA.

Wegrecki M, et al. (2015 Dec 15). The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two β-propellers during the assembly of large ribosomal subunits in eukaryotes.

Thoms M, et al. (2016 Jan 29). Concerted removal of the Erb1-Ytm1 complex in ribosome biogenesis relies on an elaborate interface.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 2 genes with posterior transmembrane prediction > 50%