FOG11561
EOG8PRRBP

sce:TRM112

Genes: 32

SGD Description
Protein involved in methylation of tRNA, rRNA, and translation factors; also involved in ribosome biogenesis; subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; interacts with and stabilizes 18S rRNA methyltransferase Bud23p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; relative distribution to the nucleus increases upon DNA replication stress


PomBase Description
protein and tRNA methyltransferase regulatory subunit Trm112 (predicted)


AspGD Description
Ortholog(s) have protein methyltransferase activity, rRNA (guanine) methyltransferase activity, tRNA (guanine-N2-)-methyltransferase activity


References

Purushothaman SK, et al. (2005 Jun). Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA.

Heurgué-Hamard V, et al. (2006 Nov 24). The zinc finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast.

Figaro S, et al. (2012 Jun). Trm112 is required for Bud23-mediated methylation of the 18S rRNA at position G1575.

Sardana R, et al. (2012 Nov). The methyltransferase adaptor protein Trm112 is involved in biogenesis of both ribosomal subunits.

Létoquart J, et al. (2015 Dec 15). Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 0 genes with posterior transmembrane prediction > 50%