FOG11298
EOG8QJQ3G

sce:RPG1

Genes: 33

SGD Description
eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3); subunit of the core complex of eIF3; essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation


PomBase Description
translation initiation factor eIF3a


AspGD Description
Ortholog(s) have role in regulation of translation in response to nitrogen starvation


References

Phan L, et al. (1998 Aug). Identification of a translation initiation factor 3 (eIF3) core complex, conserved in yeast and mammals, that interacts with eIF5.

Valásek L, et al. (1998 Aug 14). Rpg1, the Saccharomyces cerevisiae homologue of the largest subunit of mammalian translation initiation factor 3, is required for translational activity.

Vornlocher HP, et al. (1999 Jun 11). A 110-kilodalton subunit of translation initiation factor eIF3 and an associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes.

Phan L, et al. (2001 Jun 1). A subcomplex of three eIF3 subunits binds eIF1 and eIF5 and stimulates ribosome binding of mRNA and tRNA(i)Met.

Akiyoshi Y, et al. (2001 Mar 30). Fission yeast homolog of murine Int-6 protein, encoded by mouse mammary tumor virus integration site, is associated with the conserved core subunits of eukaryotic translation initiation factor 3.

Valásek L, et al. (2003 Mar 15). The yeast eIF3 subunits TIF32/a, NIP1/c, and eIF5 make critical connections with the 40S ribosome in vivo.

Gruhler A, et al. (2005 Mar). Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway.

Zhou C, et al. (2005 May 17). PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes.

Jenkins CC, et al. (2005 Nov). Activation of AP-1-dependent transcription by a truncated translation initiation factor.

Nielsen KH, et al. (2006 Apr). Interaction of the RNP1 motif in PRT1 with HCR1 promotes 40S binding of eukaryotic initiation factor 3 in yeast.

Tafforeau L, et al. (2006 Oct 4). Repression of ergosterol level during oxidative stress by fission yeast F-box protein Pof14 independently of SCF.

Malavazi I, et al. (2007 Oct). Transcriptome analysis of the Aspergillus nidulans AtmA (ATM, Ataxia-Telangiectasia mutated) null mutant.

Asp E, et al. (2008 Feb). Fission yeast mitogen-activated protein kinase Sty1 interacts with translation factors.

Wilson-Grady JT, et al. (2008 Mar). Phosphoproteome analysis of fission yeast.

Ray A, et al. (2008 Nov). Fission yeast translation initiation factor 3 subunit eIF3h is not essential for global translation initiation, but deletion of eif3h+ affects spore formation.

Zhou M, et al. (2008 Nov 25). Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3.

Szamecz B, et al. (2008 Sep 1). eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA.

Beltrao P, et al. (2009 Jun 16). Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species.

Selvanathan SP, et al. (2010 May 7). Schizosaccharomyces pombe Dss1p is a DNA damage checkpoint protein that recruits Rad24p, Cdc25p, and Rae1p to DNA double-strand breaks.

Nilsson D, et al. (2011 Jan). Cellular stress induces cytoplasmic RNA granules in fission yeast.

Zhang K, et al. (2011 Mar 25). Clr4/Suv39 and RNA quality control factors cooperate to trigger RNAi and suppress antisense RNA.

Nie M, et al. (2012 Aug 24). Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions.

Jongjitwimol J, et al. (2014). The S. pombe translation initiation factor eIF4G is Sumoylated and associates with the SUMO protease Ulp2.

Carpy A, et al. (2014 Aug). Absolute proteome and phosphoproteome dynamics during the cell cycle of Schizosaccharomyces pombe (Fission Yeast).

Bernal M, et al. (2014 Jun). Proteome-wide search for PP2A substrates in fission yeast.

Deng L, et al. (2014 Sep 1). Megadalton-node assembly by binding of Skb1 to the membrane anchor Slf1.

Beckley JR, et al. (2015 Dec). A Degenerate Cohort of Yeast Membrane Trafficking DUBs Mediates Cell Polarity and Survival.

Lucena R, et al. (2015 May 11). Nucleocytoplasmic transport in the midzone membrane domain controls yeast mitotic spindle disassembly.

Swaffer MP, et al. (2016 Dec 15). CDK Substrate Phosphorylation and Ordering the Cell Cycle.

Lee J, et al. (2017 Feb 20). Chromatin remodeller Fun30^Fft3 induces nucleosome disassembly to facilitate RNA polymerase II elongation.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 1 genes with posterior transmembrane prediction > 50%