FOG11145
EOG8QZ633

sce:VPS30

Genes: 30

SGD Description
Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has a novel globular fold that is essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of the higher eukaryotic gene Beclin 1


PomBase Description
autophagy associated beclin family protein Atg6


AspGD Description
Phosphatidylinositol 3-kinase complex subunit; predicted role in autophagy


References

Tsukada M, et al. (1993 Oct 25). Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae.

Seaman MN, et al. (1997 Apr 7). Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products.

Kametaka S, et al. (1998 Aug 28). Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae.

Kihara A, et al. (2001 Feb 5). Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae.

Suzuki K, et al. (2001 Nov 1). The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation.

Burda P, et al. (2002 Oct 15). Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase.

Obara K, et al. (2006 Apr). Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae.

Kruse KB, et al. (2006 Jan). Characterization of an ERAD gene as VPS30/ATG6 reveals two alternative and functionally distinct protein quality control pathways: one for soluble Z variant of human alpha-1 proteinase inhibitor (A1PiZ) and another for aggregates of A1PiZ.

Suzuki K, et al. (2007 Feb). Hierarchy of Atg proteins in pre-autophagosomal structure organization.

Zhang Y, et al. (2007 Jul-Aug). The role of autophagy in mitochondria maintenance: characterization of mitochondrial functions in autophagy-deficient S. cerevisiae strains.

Ma J, et al. (2007 Nov-Dec). Overexpression of autophagy-related genes inhibits yeast filamentous growth.

Hirayama H, et al. (2008 Apr). O-mannosylation is required for degradation of the endoplasmic reticulum-associated degradation substrate Gas1*p via the ubiquitin/proteasome pathway in Saccharomyces cerevisiae.

Krick R, et al. (2008 Oct). Piecemeal microautophagy of the nucleus requires the core macroautophagy genes.

Fu L, et al. (2009 Apr). ER-associated complexes (ERACs) containing aggregated cystic fibrosis transmembrane conductance regulator (CFTR) are degraded by autophagy.

Wiederhold E, et al. (2009 Feb). The yeast vacuolar membrane proteome.

Noda NN, et al. (2012 May 11). Structure of the novel C-terminal domain of vacuolar protein sorting 30/autophagy-related protein 6 and its specific role in autophagy.

Suzuki K, et al. (2013 Jun 1). Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae.

Araki Y, et al. (2013 Oct 28). Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity.

Fogel AI, et al. (2013 Sep). Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy.

Mitochondrial localization predictions
Predotar	TargetP	MitoProt
Raw data
Phobius transmembrane predictions 13 genes with posterior transmembrane prediction > 50%